Gold Nanoparticles Prepared with Phyllanthus emblica Fruit Extract and Bifidobacterium animalis subsp. lactis Can Induce Apoptosis via Mitochondrial Impairment with Inhibition of Autophagy in the Human Gastric Carcinoma Cell Line AGS
DC Field | Value | Language |
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dc.contributor.author | Wang, Rongbo | - |
dc.contributor.author | Xu, Xingyue | - |
dc.contributor.author | Puja, Aditi Mitra | - |
dc.contributor.author | Perumalsamy, Haribalan | - |
dc.contributor.author | Balusamy, Sri Renukadevi | - |
dc.contributor.author | Kim, Hoon | - |
dc.contributor.author | Kim, Yeon-Ju | - |
dc.date.accessioned | 2023-09-04T07:17:11Z | - |
dc.date.available | 2023-09-04T07:17:11Z | - |
dc.date.created | 2023-07-21 | - |
dc.date.issued | 2021-05 | - |
dc.identifier.issn | 20794991 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/189720 | - |
dc.description.abstract | (1) Background: Nanotechnology is being widely applied for anticancer strategies with few side effects. Nanoparticles (NPs) prepared from natural extracts are promising candidates for cancer treatment because of their unique physicochemical characteristics. This study aimed to prepare gold nanoparticles (AuNPs) from Phyllanthus emblica fruit extract (PEFE) using Bifidobacterium animalis subsp. lactis (B. lactis) and to evaluate their anticancer activity against the human gastric adenocarcinoma cell-line (AGS). (2) Methods: The safety of microbial biosynthesis AuNPs (PEFE-AuNPs) was assessed by evaluating the cytotoxicity. The anticancer activity of PEFE-AuNPs was investigated in AGS cells in terms of apoptosis and autophagy. (3) Results: PEFE-AuNPs exhibited significant cytotoxicity against AGS cells but not against normal cells. The apoptosis induced by PEFE-AuNPs in AGS cells was associated with PTEN-induced kinase 1 (PINK1)-Parkin mediated reduction of mitochondrial membrane potential and activation of intracellular signaling apoptosis pathways. The anticancer activity of PEFE-AuNPs was associated with induction of apoptosis through inhibition of autophagy, downregulation of LC3-II/LC3-I and Beclin-1 expression, and upregulation of p62 expression in AGS cells. (4) Conclusions: This study is the first to demonstrate the anticancer activity of PEFE-AuNPs against AGS cells. Our results provide a good starting point for the development of new anticancer products based on gold nanoparticles of P. emblica fruit extract. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.title | Gold Nanoparticles Prepared with Phyllanthus emblica Fruit Extract and Bifidobacterium animalis subsp. lactis Can Induce Apoptosis via Mitochondrial Impairment with Inhibition of Autophagy in the Human Gastric Carcinoma Cell Line AGS | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Perumalsamy, Haribalan | - |
dc.identifier.doi | 10.3390/nano11051260 | - |
dc.identifier.scopusid | 2-s2.0-85105484256 | - |
dc.identifier.wosid | 000657011400001 | - |
dc.identifier.bibliographicCitation | NANOMATERIALS, v.11, no.5 | - |
dc.relation.isPartOf | NANOMATERIALS | - |
dc.citation.title | NANOMATERIALS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 5 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | ChemistryScience & Technology - Other TopicsMaterials SciencePhysics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, MultidisciplinaryNanoscience & NanotechnologyMaterials Science, MultidisciplinaryPhysics, Applied | - |
dc.subject.keywordAuthor | Phyllanthus emblica fruit | - |
dc.subject.keywordAuthor | Bifidobacterium animalis subsplactis | - |
dc.subject.keywordAuthor | gold nanoparticles | - |
dc.subject.keywordAuthor | gastric cancer | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | autophagy | - |
dc.identifier.url | https://www.mdpi.com/2079-4991/11/5/1260 | - |
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