Development of Lactobacillus kimchicus DCY51T-mediated gold nanoparticles for delivery of ginsenoside compound K: in vitro photothermal effects and apoptosis detection in cancer cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Yeon-Ju | - |
dc.contributor.author | Perumalsamy, Haribalan | - |
dc.contributor.author | Markus, Josua | - |
dc.contributor.author | Balusamy, Renukadevi | - |
dc.contributor.author | Wang, Chao | - |
dc.contributor.author | Kang, Seong Ho | - |
dc.contributor.author | Lee, Seungah | - |
dc.contributor.author | Park, Sang Yong | - |
dc.contributor.author | Kim, Sung | - |
dc.contributor.author | Castro-Aceituno, Veronica | - |
dc.contributor.author | Kim, Seung Hyun | - |
dc.contributor.author | Yang, Deok Chun | - |
dc.date.accessioned | 2023-09-04T07:32:55Z | - |
dc.date.available | 2023-09-04T07:32:55Z | - |
dc.date.created | 2023-07-21 | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 2169-1401 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/189829 | - |
dc.description.abstract | We report a non-covalent loading of ginsenoside compound K (CK) onto our previously reported gold nanoparticles (DCY51(T)-AuCKNps) through one-pot biosynthesis using a probiotic Lactobacillus kimchicus DCY51(T) isolated from Korean kimchi. The ginsenoside-loaded gold nanoparticles were characterized by various analytical and spectroscopic techniques such as field emission transmission electron microscopy (FE-TEM), energy-dispersive X-ray (EDX) spectroscopy, elemental mapping, X-ray powder diffraction (XRD), selected area electron diffraction (SAED), Fourier-transform infrared (FTIR) spectroscopy and dynamic light scattering (DLS). Furthermore, drug loading was also determined by liquid chromatography-mass spectrometry (LC-MS). In addition, DCY51(T)-AuNps and DCY51(T)-AuCKNps were resistant to aggregation caused by pH variation or a high ionic strength environment. Cell-based study confirmed that DCY51(T)-AuCKNps exhibited slightly higher cytotoxicity compared to ginsenoside CK treatment in A549 cells (human lung adenocarcinoma cell line) and HT29 (human colorectal adenocarcinoma cell line). Upon laser treatment, DCY51(T)-AuCKNps showed enhanced cell apoptosis in A549, HT29 and AGS cells (human stomach gastric adenocarcinoma cell line) compared with only DCY51(T)-AuCKNps treated cells. In conclusion, this preliminary study identified that DCY51(T)-AuCKNps act as a potent photothermal therapy agents with synergistic chemotherapeutic effects for the treatment of cancer. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Development of Lactobacillus kimchicus DCY51T-mediated gold nanoparticles for delivery of ginsenoside compound K: in vitro photothermal effects and apoptosis detection in cancer cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Perumalsamy, Haribalan | - |
dc.identifier.doi | 10.1080/21691401.2018.1541900 | - |
dc.identifier.scopusid | 2-s2.0-85060178727 | - |
dc.identifier.wosid | 000457060100001 | - |
dc.identifier.bibliographicCitation | Artificial Cells, Nanomedicine, and Biotechnology, v.47, no.1, pp.30 - 44 | - |
dc.relation.isPartOf | Artificial Cells, Nanomedicine, and Biotechnology | - |
dc.citation.title | Artificial Cells, Nanomedicine, and Biotechnology | - |
dc.citation.volume | 47 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 30 | - |
dc.citation.endPage | 44 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | SILVER NANOPARTICLES | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | GREEN SYNTHESIS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | COALESCENCE | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordPlus | NANORODS | - |
dc.subject.keywordPlus | TUMORS | - |
dc.subject.keywordPlus | PH | - |
dc.subject.keywordAuthor | Ginsenoside CK | - |
dc.subject.keywordAuthor | gold nanoparticles | - |
dc.subject.keywordAuthor | photothermal therapy | - |
dc.subject.keywordAuthor | photoluminescence | - |
dc.subject.keywordAuthor | drug delivery | - |
dc.subject.keywordAuthor | green synthesis | - |
dc.subject.keywordAuthor | anticancer activity | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.1080/21691401.2018.1541900 | - |
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