Antiviral effects and possible mechanisms of action of constituents from Brazilian propolis and related compounds
DC Field | Value | Language |
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dc.contributor.author | Kwon, Min Jung | - |
dc.contributor.author | Shin, He Min | - |
dc.contributor.author | Perumalsamy, Haribalan | - |
dc.contributor.author | Wang, Xue | - |
dc.contributor.author | Ahn, Young-Joon | - |
dc.date.accessioned | 2023-09-04T07:33:10Z | - |
dc.date.available | 2023-09-04T07:33:10Z | - |
dc.date.created | 2023-07-21 | - |
dc.date.issued | 2020-08 | - |
dc.identifier.issn | 0021-8839 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/189830 | - |
dc.description.abstract | Propolis is a well-known medicinal bee hive product amongst others due to its antiviral properties. Human rhinoviruses (HRVs) are recognized to be responsible for more than 50% of common colds worldwide. This study was performed to determine if kaempferol (KF) and p-coumaric acid (p-CA) extracted from Brazilian propolis and another eight previously known compounds of propolis had antiviral activity toward human rhinovirus (HRV)-2, HRV-3, and HRV-4 in HeLa cells and to determine their mechanism of action using sulforhodamine B assay and real-time reverse transcription polymerase chain reaction. Results were compared with those of a positive control ribavirin. Based on IC50 values, KF, quercetin, chrysin, and luteolin were more pronounced in antiviral activity toward HRV-2 (7.3-37.4 mu M), HRV-3 (11.9-20.4 mu M), and HRV-4 (12.9-24.4 mu M) than a drug reference ribavirin (270.1-323.9 mu M). The 35 mu M KF and 610 mu M p-CA did not interact with the HRV-3 particles. KF and p-CA inhibited HRV-3 infection when added during the early stages (0-4 h) after virus inoculation. These constituents remarkably reduced the RNA replication levels of HRV-3 in the HeLa cell cultures. These findings suggest that KF and p-CA may block or reduce the entrance of the viruses into the cells to protect the cells from the virus destruction and abate virus replication, which may play a crucial role in interfering with expressions of intercellular adhesion molecule-1 and interleukin-6. Further studies about the possible applications of propolis-derived materials as potential products to prevent or treat HRV infection are warranted. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Antiviral effects and possible mechanisms of action of constituents from Brazilian propolis and related compounds | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Perumalsamy, Haribalan | - |
dc.identifier.doi | 10.1080/00218839.2019.1695715 | - |
dc.identifier.scopusid | 2-s2.0-85075952469 | - |
dc.identifier.wosid | 000500668800001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF APICULTURAL RESEARCH, v.59, no.4, pp.413 - 425 | - |
dc.relation.isPartOf | JOURNAL OF APICULTURAL RESEARCH | - |
dc.citation.title | JOURNAL OF APICULTURAL RESEARCH | - |
dc.citation.volume | 59 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 413 | - |
dc.citation.endPage | 425 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Entomology | - |
dc.relation.journalWebOfScienceCategory | Entomology | - |
dc.subject.keywordPlus | INHIBITS RHINOVIRUS INFECTION | - |
dc.subject.keywordPlus | RESPIRATORY-INFECTIONS | - |
dc.subject.keywordPlus | NATURAL-PRODUCTS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | RIBAVIRIN | - |
dc.subject.keywordPlus | INTERLEUKIN-8 | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | DISCOVERY | - |
dc.subject.keywordAuthor | propolis | - |
dc.subject.keywordAuthor | human rhinovirus | - |
dc.subject.keywordAuthor | p-coumaric acid | - |
dc.subject.keywordAuthor | kaempferol | - |
dc.subject.keywordAuthor | mechanism of action | - |
dc.subject.keywordAuthor | natural antiviral agent | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.1080/00218839.2019.1695715 | - |
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