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Antiviral effects and possible mechanisms of action of constituents from Brazilian propolis and related compounds

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dc.contributor.authorKwon, Min Jung-
dc.contributor.authorShin, He Min-
dc.contributor.authorPerumalsamy, Haribalan-
dc.contributor.authorWang, Xue-
dc.contributor.authorAhn, Young-Joon-
dc.date.accessioned2023-09-04T07:33:10Z-
dc.date.available2023-09-04T07:33:10Z-
dc.date.created2023-07-21-
dc.date.issued2020-08-
dc.identifier.issn0021-8839-
dc.identifier.urihttps://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/189830-
dc.description.abstractPropolis is a well-known medicinal bee hive product amongst others due to its antiviral properties. Human rhinoviruses (HRVs) are recognized to be responsible for more than 50% of common colds worldwide. This study was performed to determine if kaempferol (KF) and p-coumaric acid (p-CA) extracted from Brazilian propolis and another eight previously known compounds of propolis had antiviral activity toward human rhinovirus (HRV)-2, HRV-3, and HRV-4 in HeLa cells and to determine their mechanism of action using sulforhodamine B assay and real-time reverse transcription polymerase chain reaction. Results were compared with those of a positive control ribavirin. Based on IC50 values, KF, quercetin, chrysin, and luteolin were more pronounced in antiviral activity toward HRV-2 (7.3-37.4 mu M), HRV-3 (11.9-20.4 mu M), and HRV-4 (12.9-24.4 mu M) than a drug reference ribavirin (270.1-323.9 mu M). The 35 mu M KF and 610 mu M p-CA did not interact with the HRV-3 particles. KF and p-CA inhibited HRV-3 infection when added during the early stages (0-4 h) after virus inoculation. These constituents remarkably reduced the RNA replication levels of HRV-3 in the HeLa cell cultures. These findings suggest that KF and p-CA may block or reduce the entrance of the viruses into the cells to protect the cells from the virus destruction and abate virus replication, which may play a crucial role in interfering with expressions of intercellular adhesion molecule-1 and interleukin-6. Further studies about the possible applications of propolis-derived materials as potential products to prevent or treat HRV infection are warranted.-
dc.language영어-
dc.language.isoen-
dc.publisherTAYLOR & FRANCIS LTD-
dc.titleAntiviral effects and possible mechanisms of action of constituents from Brazilian propolis and related compounds-
dc.typeArticle-
dc.contributor.affiliatedAuthorPerumalsamy, Haribalan-
dc.identifier.doi10.1080/00218839.2019.1695715-
dc.identifier.scopusid2-s2.0-85075952469-
dc.identifier.wosid000500668800001-
dc.identifier.bibliographicCitationJOURNAL OF APICULTURAL RESEARCH, v.59, no.4, pp.413 - 425-
dc.relation.isPartOfJOURNAL OF APICULTURAL RESEARCH-
dc.citation.titleJOURNAL OF APICULTURAL RESEARCH-
dc.citation.volume59-
dc.citation.number4-
dc.citation.startPage413-
dc.citation.endPage425-
dc.type.rimsART-
dc.type.docType정기학술지(Article(Perspective Article포함))-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaEntomology-
dc.relation.journalWebOfScienceCategoryEntomology-
dc.subject.keywordPlusINHIBITS RHINOVIRUS INFECTION-
dc.subject.keywordPlusRESPIRATORY-INFECTIONS-
dc.subject.keywordPlusNATURAL-PRODUCTS-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusRIBAVIRIN-
dc.subject.keywordPlusINTERLEUKIN-8-
dc.subject.keywordPlusPATHOGENESIS-
dc.subject.keywordPlusASSOCIATION-
dc.subject.keywordPlusFLAVONOIDS-
dc.subject.keywordPlusDISCOVERY-
dc.subject.keywordAuthorpropolis-
dc.subject.keywordAuthorhuman rhinovirus-
dc.subject.keywordAuthorp-coumaric acid-
dc.subject.keywordAuthorkaempferol-
dc.subject.keywordAuthormechanism of action-
dc.subject.keywordAuthornatural antiviral agent-
dc.identifier.urlhttps://www.tandfonline.com/doi/full/10.1080/00218839.2019.1695715-
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