Comparison of outcomes of cyclosporine A and infliximab for steroid-refractory acute severe ulcerative colitis
DC Field | Value | Language |
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dc.contributor.author | Song, Eun Mi | - |
dc.contributor.author | Oh, Eun Hye | - |
dc.contributor.author | Hwang, Sung Wook | - |
dc.contributor.author | Park, Sang Hyoung | - |
dc.contributor.author | Yang, Dong-Hoon | - |
dc.contributor.author | Byeon, Jeong-Sik | - |
dc.contributor.author | Myung, Seung-Jae | - |
dc.contributor.author | Yang, Suk-Kyun | - |
dc.contributor.author | Ye, Byong Duk | - |
dc.date.accessioned | 2023-09-11T01:49:18Z | - |
dc.date.available | 2023-09-11T01:49:18Z | - |
dc.date.created | 2023-07-21 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 0815-9319 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/190356 | - |
dc.description.abstract | Background and Aim Data comparing the outcomes of cyclosporin A (CsA) and infliximab (IFX) as rescue therapy for steroid-refractory acute severe ulcerative colitis (SR-ASUC) among Asians are scarce. Methods In this single-center study, we retrospectively reviewed 121 patients with SR-ASUC according to the Truelove and Witts' criteria who received CsA or IFX as rescue therapy between 1995 and 2015. The cumulative rates of treatment failure and colectomy at 3 months were compared. Treatment failure was defined as colectomy, switch to other medications, acute flare-up events requiring steroid treatment, or adverse events leading to drug interruption. Results Among 121 patients with SR-ASUC (male, 55.6%; median disease duration, 47.1 months; extensive colitis, 61.2%), 23 received CsA as rescue therapy. Baseline characteristics (e.g. age at diagnosis, sex, disease duration, disease extent at rescue therapy, and Mayo score at treatment initiation) were comparable between the two groups. During follow-up (median, 45 months; interquartile range 29.3-61.8), 84 patients (69.4%) experienced treatment failure, and 25 patients (20.7%) underwent colectomy. The CsA group and the IFX group did not show significant differences in the cumulative rates of treatment failure (39.1% vs 34.7%, P = 0.714) and colectomy (26.1% vs 13.3%, P = 0.198) at 3 months. Previous use of azathioprine (odds ratio [OR] = 2.309, 95% confidence interval [CI] = 1.076-4.951, P = 0.032) was associated with treatment failure at 3 months. Mayo score > 10 at the time of rescue therapy was significantly associated with colectomy at 3 months (OR = 8.444, 95% CI = 2.592-27.506, P < 0.001). Conclusion Among Korean patients with SR-ASUC, the rates of treatment failure and colectomy at 3 months were not significantly different between the CSA and the IFX treatment groups. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Comparison of outcomes of cyclosporine A and infliximab for steroid-refractory acute severe ulcerative colitis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Oh, Eun Hye | - |
dc.identifier.doi | 10.1111/jgh.15508 | - |
dc.identifier.scopusid | 2-s2.0-85104539631 | - |
dc.identifier.wosid | 000640874900001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, v.36, no.9, pp.2463 - 2470 | - |
dc.relation.isPartOf | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | - |
dc.citation.title | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | - |
dc.citation.volume | 36 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 2463 | - |
dc.citation.endPage | 2470 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordAuthor | colectomy | - |
dc.subject.keywordAuthor | cyclosporine | - |
dc.subject.keywordAuthor | infliximab | - |
dc.subject.keywordAuthor | ulcerative colitis | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/jgh.15508 | - |
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