Efficacy and safety of autologous adipose tissue-derived stem cell therapy for children with refractory Crohn's complex fistula: a Phase IV clinical study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Yu Jeong | - |
dc.contributor.author | Kwon, Hyunhee | - |
dc.contributor.author | Kwon, Yong Jae | - |
dc.contributor.author | Kim, Kyung Mo | - |
dc.contributor.author | Oh, Seak Hee | - |
dc.contributor.author | Kim, Dae Yeon | - |
dc.date.accessioned | 2023-09-18T06:35:04Z | - |
dc.date.available | 2023-09-18T06:35:04Z | - |
dc.date.created | 2023-07-21 | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 2288-6575 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/190669 | - |
dc.description.abstract | Purpose: Autologous adipose tissue-derived stem cells (ASCs) have been proposed for patients with refractory Crohn disease, but research is lacking in pediatric patients. This Phase IV study evaluated the efficacy and safety of ASCs in children with refractory Crohn's fistulae. Methods: Patients with a refractory Crohn's fistula who did not have conventional therapy for more than 3 months or with a recurrent complex Crohn's fistula were included. All patients were at least 14 years old. Patients with infection, poor condition, or active Crohn disease with a disease activity index of 450 and above were excluded. Five patients were treated with ASCs from 2014 to 2015 in Asan Medical Center. ASC administration was adjusted according to fistula size (1 mL per cm(2)). We evaluated the efficacy and safety 8 weeks after injection and followed patients for 6 months. Results: Fistulae were healed in 4 patients by 8 weeks after ASC injection. Of these 4 patients, 1 had complete fistula closure and sustainability after 6 months. The other 3 with healing effects had less than 50% fistula closure by 6 months. None of these 4 patients have persistent fistulae. One patient had no healing effect, and seton ligation was performed 8 months after ASC injection. There were no adverse effects related to ASC administration. Conclusion: ASC therapy is a simple and well-tolerated therapeutic option for children with refractory Crohn's complex fistulae. Complete closure was well-sustained. However, more data from a larger number of patients are needed. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SURGICAL SOCIETY | - |
dc.title | Efficacy and safety of autologous adipose tissue-derived stem cell therapy for children with refractory Crohn's complex fistula: a Phase IV clinical study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cho, Yu Jeong | - |
dc.identifier.doi | 10.4174/astr.2021.101.1.58 | - |
dc.identifier.scopusid | 2-s2.0-85109607019 | - |
dc.identifier.wosid | 000671943800007 | - |
dc.identifier.bibliographicCitation | ANNALS OF SURGICAL TREATMENT AND RESEARCH | - |
dc.relation.isPartOf | ANNALS OF SURGICAL TREATMENT AND RESEARCH | - |
dc.citation.title | ANNALS OF SURGICAL TREATMENT AND RESEARCH | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject.keywordPlus | PERIANAL FISTULA | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | INFLIXIMAB | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | ONSET | - |
dc.subject.keywordAuthor | Autologous stem cells | - |
dc.subject.keywordAuthor | Mesenchymal stem cells | - |
dc.subject.keywordAuthor | Pediatric Crohn&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.identifier.url | https://astr.or.kr/DOIx.php?id=10.4174/astr.2021.101.1.58 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.