Fatal outcome of severe fever with thrombocytopenia syndrome (SFTS) and severe and critical COVID-19 is associated with the hyperproduction of IL-10 and IL-6 and the low production of TGF-β
DC Field | Value | Language |
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dc.contributor.author | Kang, Su Yeon | - |
dc.contributor.author | Yoo, Jeong Rae | - |
dc.contributor.author | Park, Yejin | - |
dc.contributor.author | Kim, So-Hee | - |
dc.contributor.author | Heo, Sang Taek | - |
dc.contributor.author | Park, Seong Hyeon | - |
dc.contributor.author | Kim, Misun | - |
dc.contributor.author | Kim, Tae-Jin | - |
dc.contributor.author | Oh, Songhyeok | - |
dc.contributor.author | Lee, Moo-Seung | - |
dc.contributor.author | Kim, Jung Mogg | - |
dc.contributor.author | Cho, Nam-Hyuk | - |
dc.contributor.author | Lee, Kyung-Mi | - |
dc.contributor.author | Lee, Keun Hwa | - |
dc.date.accessioned | 2023-09-18T06:37:02Z | - |
dc.date.available | 2023-09-18T06:37:02Z | - |
dc.date.created | 2023-07-20 | - |
dc.date.issued | 2023-07 | - |
dc.identifier.issn | 0146-6615 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/190682 | - |
dc.description.abstract | Severe fever with thrombocytopenia syndrome virus (SFTSV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause the hyperproduction of inflammatory cytokines, which have pathological effects in patient including severe or fatal cytokine storms. To characterize the effect of SFTSV and SARS-CoV-2 infection on the production of cytokines in severe fever with thrombocytopenia syndrome (SFTS) and COVID-19 patients, we performed an analysis of cytokines in SFTS and COVID-19 patients and also investigated the role of interleukin-10 (IL-10) in vitro studies: lipopolysaccharide-induced THP-1-derived macrophages, SFTSV infection of THP-1 cells, and SARS-CoV-2 infection of THP-1 cells. In this study, we found that levels of both IL-10 and IL-6 were significantly elevated, the level of transforming growth factor-β (TGF-β) was significantly decreased and IL-10 was elevated earlier than IL-6 in severe and critical COVID-19 and fatal SFTS patients, and inhibition of IL-10 signaling decreased the production of IL-6 and elevated that of TGF-β. Therefore, the hyperproduction of IL-10 and IL-6 and the low production of TGF-β have been linked to cytokine storm-induced mortality in fatal SFTS and severe and critically ill COVID-19 patients and that IL-10 can play an important role in the host immune response to severe and critical SARS-CoV-2 and fatal SFTSV infection. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Fatal outcome of severe fever with thrombocytopenia syndrome (SFTS) and severe and critical COVID-19 is associated with the hyperproduction of IL-10 and IL-6 and the low production of TGF-β | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jung Mogg | - |
dc.contributor.affiliatedAuthor | Lee, Keun Hwa | - |
dc.identifier.doi | 10.1002/jmv.28894 | - |
dc.identifier.scopusid | 2-s2.0-85164233324 | - |
dc.identifier.wosid | 001038390400074 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MEDICAL VIROLOGY, v.95, no.7, pp.1 - 9 | - |
dc.relation.isPartOf | JOURNAL OF MEDICAL VIROLOGY | - |
dc.citation.title | JOURNAL OF MEDICAL VIROLOGY | - |
dc.citation.volume | 95 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Virology | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.subject.keywordPlus | DISEASE SEVERITY | - |
dc.subject.keywordAuthor | COVID-19 | - |
dc.subject.keywordAuthor | cytokine storm | - |
dc.subject.keywordAuthor | IL-10 | - |
dc.subject.keywordAuthor | IL-6 | - |
dc.subject.keywordAuthor | SFTS | - |
dc.subject.keywordAuthor | TGF-β | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/jmv.28894 | - |
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