Protective Effects of Euphrasia officinalis Extract against Ultraviolet B-Induced Photoaging in Normal Human Dermal Fibroblasts
DC Field | Value | Language |
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dc.contributor.author | Liu, Ying | - |
dc.contributor.author | Hwang, Eunson | - |
dc.contributor.author | Ngo, Hien T. T. | - |
dc.contributor.author | Perumalsamy, Haribalan | - |
dc.contributor.author | Kim, Yeon Ju | - |
dc.contributor.author | Li, Lu | - |
dc.contributor.author | Yi, Tae-Hoo | - |
dc.date.accessioned | 2023-09-18T07:02:50Z | - |
dc.date.available | 2023-09-18T07:02:50Z | - |
dc.date.created | 2023-07-07 | - |
dc.date.issued | 2018-11 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/190851 | - |
dc.description.abstract | Ultraviolet (UV) radiation induces skin photoaging, which is associated with the elevation of matrix metalloproteinases (MMPs) and the impairment of collagen. The Euphrasia species play a well-known role in the treatment of certain eye disorders through their anti-oxidative and anti-inflammatory activities. However, their protective activity toward UVB-induced damage remains unclear. In the present study, we investigated the protective effect of Euphrasia officinalis (95% ethanol extract) on UVB-irradiated photoaging in normal human dermal fibroblasts (NHDFs). Our results show that Euphrasia officinalis extract exhibited obvious reactive oxygen species (ROS) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activity, enhanced NHDF cell migration, and reduced UVB-induced apoptosis. The UVB-induced increases in MMP-1 and MMP-3 and decrease in type I procollagen were ameliorated by Euphrasia officinalis treatment, which worked by suppressing the mitogen-activated protein kinase (MAPK) and nuclear transcription factor activator protein 1 (AP-1) signaling pathways. Taken together, our data strongly suggest that Euphrasia officinalis ethanol extract could reduce UVB-induced photoaging by alleviating oxidative stress, proinflammatory activity, and cell apoptosis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.title | Protective Effects of Euphrasia officinalis Extract against Ultraviolet B-Induced Photoaging in Normal Human Dermal Fibroblasts | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Perumalsamy, Haribalan | - |
dc.identifier.doi | 10.3390/ijms19113327 | - |
dc.identifier.scopusid | 2-s2.0-85055612391 | - |
dc.identifier.wosid | 000451528500043 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.19, no.11, pp.1 - 14 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 19 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 14 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | COLLAGEN | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | Euphrasia officinalis | - |
dc.subject.keywordAuthor | ultraviolet B | - |
dc.subject.keywordAuthor | photoaging | - |
dc.subject.keywordAuthor | matrix metalloproteinases | - |
dc.subject.keywordAuthor | type I procollagen | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.identifier.url | https://www.mdpi.com/1422-0067/19/11/3327 | - |
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