Increased Risk of Exacerbation in Asthma Predominant Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Jisoo | - |
dc.contributor.author | Kim, Eun-Kyung | - |
dc.contributor.author | Kim, Mi-Ae | - |
dc.contributor.author | Kim, Tae-Hyung | - |
dc.contributor.author | Chang, Jung Hyun | - |
dc.contributor.author | Ryu, Yon Ju | - |
dc.contributor.author | Lee, Sei Won | - |
dc.contributor.author | Oh, Yeon-Mok | - |
dc.contributor.author | Yong, Suk Joong | - |
dc.contributor.author | Choi, Wonil | - |
dc.contributor.author | Yoo, Kwang Ha | - |
dc.contributor.author | Lee, Ji-Hyun | - |
dc.date.accessioned | 2023-09-18T07:20:17Z | - |
dc.date.available | 2023-09-18T07:20:17Z | - |
dc.date.created | 2023-07-07 | - |
dc.date.issued | 2018-10 | - |
dc.identifier.issn | 1738-3536 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/190980 | - |
dc.description.abstract | Background: Obstructive airway disease patients with increased variability of airflow and incompletely reversible airflow obstruction are often categorized as having asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS). ACOS is heterogeneous with two sub-phenotypes: asthma-ACOS and COPD-ACOS. The objective of this study was to determine the difference in risk of exacerbation between the two sub-phenotypes of ACOS. Methods: A total of 223 patients exhibiting incompletely reversible airflow obstruction with increased variability (spirometrically defined ACOS) were enrolled. These patients were divided into asthma-ACOS and COPD-ACOS according to their physician's diagnosis and smoking history of 10 pack-years. Within-group comparisons were made for asthma-ACOS versus COPD-ACOS and light smokers versus heavy smokers. Results: Compared to patients with COPD-ACOS, patients with asthma-ACOS experienced exacerbation more often despite their younger age, history of light smoking, and better lung function. While the light-smoking group showed better lung function, they made unscheduled outpatient clinic visits more frequently. On multivariate analysis, asthma-ACOS and poor inhaler compliance were significantly associated with more than two unscheduled clinic visits during the previous year. Conclusion: Spirometrically defined ACOS includes heterogeneous subgroups with different clinical features. Phenotyping of ACOS by physician's diagnosis could be significant in predicting future risk of exacerbation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Korean National Tuberculosis Association | - |
dc.title | Increased Risk of Exacerbation in Asthma Predominant Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Wonil | - |
dc.identifier.doi | 10.4046/trd.2017.0064 | - |
dc.identifier.scopusid | 2-s2.0-85055272185 | - |
dc.identifier.wosid | 000445291700004 | - |
dc.identifier.bibliographicCitation | Tuberculosis and Respiratory Diseases, v.81, no.4, pp.289 - 298 | - |
dc.relation.isPartOf | Tuberculosis and Respiratory Diseases | - |
dc.citation.title | Tuberculosis and Respiratory Diseases | - |
dc.citation.volume | 81 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 289 | - |
dc.citation.endPage | 298 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.identifier.kciid | ART002393334 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | LUNG-FUNCTION | - |
dc.subject.keywordPlus | CIGARETTE-SMOKING | - |
dc.subject.keywordPlus | COPD | - |
dc.subject.keywordPlus | DECLINE | - |
dc.subject.keywordPlus | ADULTS | - |
dc.subject.keywordPlus | HOSPITALIZATIONS | - |
dc.subject.keywordPlus | PHENOTYPE | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | SEVERITY | - |
dc.subject.keywordPlus | CARE | - |
dc.subject.keywordAuthor | Asthma | - |
dc.subject.keywordAuthor | Pulmonary Disease | - |
dc.subject.keywordAuthor | Chronic Obstructive | - |
dc.subject.keywordAuthor | Phenotype | - |
dc.identifier.url | https://e-trd.org/journal/view.php?doi=10.4046/trd.2017.0064 | - |
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