Sex differences in gastrointestinal dysfunction among patients with Parkinson’s disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chang, Hee Jin | - |
dc.contributor.author | Shin, Cheol-Min | - |
dc.contributor.author | Cho, Jin Whan | - |
dc.contributor.author | Koh, Seong-Beom | - |
dc.contributor.author | Yang, YoungSoon | - |
dc.contributor.author | Kim, Hee Tae | - |
dc.contributor.author | Kim, Jong-Min | - |
dc.contributor.author | Lee, Jee-Young | - |
dc.date.accessioned | 2023-09-26T07:36:39Z | - |
dc.date.available | 2023-09-26T07:36:39Z | - |
dc.date.created | 2023-03-08 | - |
dc.date.issued | 2023-07 | - |
dc.identifier.issn | 1590-1874 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/191064 | - |
dc.description.abstract | Background and objective: Sex differences in gastrointestinal dysfunction have not been systematically analyzed in patients with Parkinson’s disease (PD). This study was aimed to investigate the sex differences in gastrointestinal dysfunctions among the patients with PD using a multicenter trial dataset. Methods: We analyzed the baseline data of prospectively enrolled set of patients with gastrointestinal dysfunctions. Possible sex differences in gastrointestinal symptoms assessed on the Nepean Dyspepsia Index-Korean Version (NDI-K), gastrointestinal symptom diary, and Bristol stool scale were analyzed in association with clinical PD severity and antiparkinsonian drug dosages by multiple linear regression models. We also performed post hoc analysis of the dyspepsia symptom sub-items, adjusting for multiple comparisons. Results: Sixty-six of the 144 participants were female (45.8%). There were no differences in age, PD duration, Hoehn and Yahr stage, and daily dopaminergic medication dosages between sexes. NDI-K symptom and dyspepsia scores were correlated with the activity of daily living in females but not in males. In the multiple regression analysis controlling for all possible variables, female patients were shown to have worse gastrointestinal symptoms than males. When we performed post hoc analysis of the dyspepsia symptoms, inability to finish a regular meal and nausea were significantly worse in female patients. Gastrointestinal symptom diary supported that female patients more frequently complained of early fullness and bloating in the upper abdomen after meals than males, and burning pain in upper abdomen was more severe in female patients. Conclusion: Gastrointestinal dysfunctions may differentially affect female and male PD patients. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Springer-Verlag Italia s.r.l. | - |
dc.title | Sex differences in gastrointestinal dysfunction among patients with Parkinson’s disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hee Tae | - |
dc.identifier.doi | 10.1007/s10072-023-06710-2 | - |
dc.identifier.scopusid | 2-s2.0-85149018839 | - |
dc.identifier.wosid | 000941254900001 | - |
dc.identifier.bibliographicCitation | Neurological Sciences, v.44, no.7, pp.2375 - 2384 | - |
dc.relation.isPartOf | Neurological Sciences | - |
dc.citation.title | Neurological Sciences | - |
dc.citation.volume | 44 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 2375 | - |
dc.citation.endPage | 2384 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | QUALITY-OF-LIFE | - |
dc.subject.keywordPlus | IRRITABLE-BOWEL-SYNDROME | - |
dc.subject.keywordPlus | FUNCTIONAL DYSPEPSIA | - |
dc.subject.keywordPlus | GENDER | - |
dc.subject.keywordPlus | HEALTH | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | SCALE | - |
dc.subject.keywordPlus | AGE | - |
dc.subject.keywordPlus | DISORDERS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordAuthor | Parkinson&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | Sex difference | - |
dc.subject.keywordAuthor | Gastrointestinal dysfunction | - |
dc.subject.keywordAuthor | NDI | - |
dc.subject.keywordAuthor | Dyspepsia | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s10072-023-06710-2 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.