Development of a Scoring System to Differentiate Severe Fever with Thrombocytopenia Syndrome from Scrub Typhus
DC Field | Value | Language |
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dc.contributor.author | Sul, Hyoung | - |
dc.contributor.author | Yun, Na Ra | - |
dc.contributor.author | Kim, Dong-Min | - |
dc.contributor.author | Kim, Young Keun | - |
dc.contributor.author | Kim, Jieun | - |
dc.contributor.author | Hur, Jian | - |
dc.contributor.author | Jung, Sook In | - |
dc.contributor.author | Ryu, Seong Yeol | - |
dc.contributor.author | Lee, Ji Yeon | - |
dc.contributor.author | Huh, Kyungmin | - |
dc.contributor.author | Kwak, Yee Gyung | - |
dc.contributor.author | Jeong, Hye Won | - |
dc.contributor.author | Heo, Jung Yeon | - |
dc.contributor.author | Jung, Dong Sik | - |
dc.contributor.author | Lee, Sun Hee | - |
dc.contributor.author | Park, Sun Hee | - |
dc.contributor.author | Yeom, Joon-Sup | - |
dc.contributor.author | Lee, Hyungdon | - |
dc.date.accessioned | 2023-09-26T08:45:59Z | - |
dc.date.available | 2023-09-26T08:45:59Z | - |
dc.date.created | 2022-06-29 | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 1999-4915 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/191189 | - |
dc.description.abstract | Severe fever with thrombocytopenia syndrome (SFTS) and scrub typhus are disorders with similar clinical features; therefore, differentiating between them is difficult. We retrospectively collected data from 183 SFTS and 178 scrub typhus patients and validated an existing scoring system to develop a more sensitive, specific, and objective scoring system. We first applied the scoring systems proposed by Kim et al. to differentiate SFTS from scrub typhus. Multivariable logistic regression revealed that altered mental status, leukopenia, prolonged activated partial thromboplastin time (aPTT), and normal C-reactive protein (CRP) level (<= 1.0 mg/dL) were significantly associated with SFTS. We changed the normal CRP level from <= 1.0 mg/dL to <= 3.0 mg/dL and replaced altered mental status with the creatine kinase (CK) level. The modified scoring system showed 97% sensitivity and 96% specificity for SFTS (area under the curve (AUC): 0.983) and a higher accuracy than the original scoring system (p = 0.0308). This study's scoring system had 97% sensitivity and 98% specificity for SFTS (AUC: 0.992) and a higher accuracy than Kim et al.'s original scoring system (p = 0.0308). Our scoring system that incorporated leukopenia, prolonged aPTT, normal CRP level (<= 3.0 mg/dL), and elevated CK level (>1000 IU/L) easily differentiated SFTS from scrub typhus in an endemic area. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.title | Development of a Scoring System to Differentiate Severe Fever with Thrombocytopenia Syndrome from Scrub Typhus | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jieun | - |
dc.identifier.doi | 10.3390/v14051093 | - |
dc.identifier.scopusid | 2-s2.0-85130922331 | - |
dc.identifier.wosid | 000804328600001 | - |
dc.identifier.bibliographicCitation | VIRUSES-BASEL, v.14, no.5, pp.1 - 7 | - |
dc.relation.isPartOf | VIRUSES-BASEL | - |
dc.citation.title | VIRUSES-BASEL | - |
dc.citation.volume | 14 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 7 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Virology | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.subject.keywordPlus | activated partial thromboplastin time | - |
dc.subject.keywordPlus | alanine aminotransferase blood level | - |
dc.subject.keywordPlus | alkaline phosphatase blood level | - |
dc.subject.keywordPlus | anorexia | - |
dc.subject.keywordPlus | area under the curve | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | artificial ventilation | - |
dc.subject.keywordPlus | aspartate aminotransferase blood level | - |
dc.subject.keywordPlus | blood sampling | - |
dc.subject.keywordPlus | coughing | - |
dc.subject.keywordPlus | creatine kinase blood level | - |
dc.subject.keywordPlus | diarrhea | - |
dc.subject.keywordPlus | dyspepsia | - |
dc.subject.keywordPlus | fatigue | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | headache | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | immunofluorescence | - |
dc.subject.keywordPlus | leukocyte count | - |
dc.subject.keywordPlus | leukocytosis | - |
dc.subject.keywordPlus | leukopenia | - |
dc.subject.keywordPlus | major clinical study | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | mental health | - |
dc.subject.keywordPlus | mortality rate | - |
dc.subject.keywordPlus | myalgia | - |
dc.subject.keywordPlus | neurologic disease | - |
dc.subject.keywordPlus | Orientia tsutsugamushi | - |
dc.subject.keywordPlus | platelet count | - |
dc.subject.keywordPlus | rash | - |
dc.subject.keywordPlus | real time polymerase chain reaction | - |
dc.subject.keywordPlus | receiver operating characteristic | - |
dc.subject.keywordPlus | retrospective study | - |
dc.subject.keywordPlus | reverse transcription polymerase chain reaction | - |
dc.subject.keywordPlus | scoring system | - |
dc.subject.keywordPlus | scrub typhus | - |
dc.subject.keywordPlus | sensitivity and specificity | - |
dc.subject.keywordPlus | severe fever with thrombocytopenia syndrome | - |
dc.subject.keywordPlus | leukopenia | - |
dc.subject.keywordPlus | Phlebovirus | - |
dc.subject.keywordPlus | scrub typhus | - |
dc.subject.keywordPlus | severe fever with thrombocytopenia syndrome | - |
dc.subject.keywordPlus | thrombocytopenia | - |
dc.subject.keywordAuthor | severe fever with thrombocytopenia syndrome | - |
dc.subject.keywordAuthor | scrub typhus | - |
dc.subject.keywordAuthor | tsutsugamushi | - |
dc.subject.keywordAuthor | differential diagnosis | - |
dc.subject.keywordAuthor | scoring system | - |
dc.identifier.url | https://www.mdpi.com/1999-4915/14/5/1093 | - |
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