Flexible 3D Nanonetworked Silica Film as a Polymer-Free Drug-Eluting Stent Platform to Effectively Suppress Tissue Hyperplasia in Rat Esophagus
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeon, Eunyoung | - |
dc.contributor.author | Kang, Jeon Min | - |
dc.contributor.author | Bae, Ga-Hyun | - |
dc.contributor.author | Zeng, Chu Hui | - |
dc.contributor.author | Shin, Seungyong | - |
dc.contributor.author | Lee, Byeongdu | - |
dc.contributor.author | Park, Wooram | - |
dc.contributor.author | Park, Jung-Hoon | - |
dc.contributor.author | Lee, Joonseok | - |
dc.date.accessioned | 2023-09-26T08:50:54Z | - |
dc.date.available | 2023-09-26T08:50:54Z | - |
dc.date.created | 2022-06-03 | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 2192-2640 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/191214 | - |
dc.description.abstract | Loading and eluting drugs on self-expandable metallic stents (SEMSs) can be challenging in terms of fabrication, mechanical stability, and therapeutic effects. In this study, a flexible 3D nanonetworked silica film (NSF) capable of withstanding mechanical stress during dynamic expansion is constructed to function as a drug delivery platform on an entire SEMS surface. Despite covering a broad curved area, the synthesized NSF is defect-free and thin enough to increase the stent strut diameter (110 µm) by only 0.4 percent (110.45 µm). The hydrophobic modification of the surface enables loading of 4.7 times the sirolimus (SRL) concentration in NSF than Cypher, polymer-coated commercial stent, which is based on the same thickness of coating layer. Furthermore, SRL-loaded NSF exhibits a twofold delay in release compared to the control group without NSF. The SRL-loaded NSF SEMS significantly suppresses stent-induced tissue hyperplasia than the control SEMS in the rat esophagus (all variables, p < 0.05). Thus, the developed NSF is a promising polymer-free drug delivery platform to efficiently treat esophageal stricture. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | John Wiley and Sons Inc | - |
dc.title | Flexible 3D Nanonetworked Silica Film as a Polymer-Free Drug-Eluting Stent Platform to Effectively Suppress Tissue Hyperplasia in Rat Esophagus | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Joonseok | - |
dc.identifier.doi | 10.1002/adhm.202200389 | - |
dc.identifier.scopusid | 2-s2.0-85130394029 | - |
dc.identifier.wosid | 000798537000001 | - |
dc.identifier.bibliographicCitation | Advanced Healthcare Materials, v.11, no.14, pp.1 - 11 | - |
dc.relation.isPartOf | Advanced Healthcare Materials | - |
dc.citation.title | Advanced Healthcare Materials | - |
dc.citation.volume | 11 | - |
dc.citation.number | 14 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 11 | - |
dc.type.rims | ART | - |
dc.type.docType | Article in Press | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | GRANULATION-TISSUE | - |
dc.subject.keywordPlus | NITINOL STENTS | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | FABRICATION | - |
dc.subject.keywordPlus | PACLITAXEL | - |
dc.subject.keywordPlus | STRICTURE | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordAuthor | drug-eluting stents | - |
dc.subject.keywordAuthor | dynamic expansion | - |
dc.subject.keywordAuthor | nanonetworked film | - |
dc.subject.keywordAuthor | polymer-free film | - |
dc.subject.keywordAuthor | restenosis | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/adhm.202200389 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.