Female Reproductive Factors and Incidence of Nontuberculous Mycobacterial Pulmonary Disease Among Postmenopausal Women in Korea
DC Field | Value | Language |
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dc.contributor.author | Choi, Hayoung | - |
dc.contributor.author | Han, Kyungdo | - |
dc.contributor.author | Yang, Bumhee | - |
dc.contributor.author | Shin, Dong Wook | - |
dc.contributor.author | Sohn, Jang Won | - |
dc.contributor.author | Lee, Hyun | - |
dc.date.accessioned | 2023-09-26T09:38:29Z | - |
dc.date.available | 2023-09-26T09:38:29Z | - |
dc.date.created | 2022-05-04 | - |
dc.date.issued | 2022-02 | - |
dc.identifier.issn | 1058-4838 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/191221 | - |
dc.description.abstract | Background There are conflicting results regarding endogenous estrogen exposure and risk of incident nontuberculous mycobacterial pulmonary disease (NTM-PD). In addition, evidence on impact of hormone replacement therapy (HRT) on risk of NTM-PD is lacking. This study aimed to evaluate the impacts of endogenous estrogen exposure and HRT on risk of NTM-PD in postmenopausal women. Methods This population-based cohort study comprised 1 400 095 postmenopausal women without previous NTM-PD who participated in the 2009 national health screening exam in South Korea. The cohort was followed until the date of incident NTM-PD, death, or December 2018. We evaluated whether lifetime endogenous estrogen exposure and HRT were associated with incident NTM-PD. Endogenous estrogen exposure was evaluated using age at menarche and menopause and reproductive period (duration between age at menarche and age at menopause). Results During a median of 8.4 (interquartile range, 8.2-8.7) years of follow-up, 0.1% of participants (1818/1 400 095) developed NTM-PD, with an incidence rate of 0.15/1000 person-years. Multivariable Cox regression analyses showed no significant relationship between endogenous estrogen exposure (age at menarche, age at menopause, and reproductive period) and risk of NTM-PD. In contrast, duration of HRT showed a significant dose-response relationship with incident NTM-PD even after adjustment for demographics and reproductive factors (adjusted hazard ratio [95% CI]: 1.30 [1.12-1.51] in HRT for <2 years; 1.28 [1.03-1.59] in 2-5 years; and 1.65 [1.33-2.05] in >= 5 years). Conclusions While there was no significant association with endogenous estrogen exposure, HRT was monotonically associated with increased risk of NTM-PD in postmenopausal women. There was a significant dose-dependent relationship between the duration of hormone replacement therapy and the risk of nontuberculous mycobacterial pulmonary disease in postmenopausal women. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS INC | - |
dc.title | Female Reproductive Factors and Incidence of Nontuberculous Mycobacterial Pulmonary Disease Among Postmenopausal Women in Korea | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Sohn, Jang Won | - |
dc.contributor.affiliatedAuthor | Lee, Hyun | - |
dc.identifier.doi | 10.1093/cid/ciac134 | - |
dc.identifier.scopusid | 2-s2.0-85129321637 | - |
dc.identifier.wosid | 000785614900001 | - |
dc.identifier.bibliographicCitation | CLINICAL INFECTIOUS DISEASES, pp.1 - 8 | - |
dc.relation.isPartOf | CLINICAL INFECTIOUS DISEASES | - |
dc.citation.title | CLINICAL INFECTIOUS DISEASES | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | AVIUM COMPLEX | - |
dc.subject.keywordPlus | ADIPONECTIN | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | ESTROGEN | - |
dc.subject.keywordAuthor | female | - |
dc.subject.keywordAuthor | estrogen | - |
dc.subject.keywordAuthor | reproductive period | - |
dc.subject.keywordAuthor | hormone replacement therapy | - |
dc.subject.keywordAuthor | nontuberculous mycobacteria | - |
dc.identifier.url | https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciac134/6528524 | - |
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