Inflammatory response to Trichomonas vaginalis in the pathogenesis of prostatitis and benign prostatic hyperplasia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Ik-Hwan | - |
dc.contributor.author | Kim, Jung-Hyun | - |
dc.contributor.author | Ryu, Jae Sook | - |
dc.date.accessioned | 2023-10-10T02:30:34Z | - |
dc.date.available | 2023-10-10T02:30:34Z | - |
dc.date.created | 2023-03-08 | - |
dc.date.issued | 2023-02 | - |
dc.identifier.issn | 2982-5164 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/191749 | - |
dc.description.abstract | <i>Trichomonas vaginalis</i> is a flagellated protozoan that causes trichomoniasis, a common nonviral sexually transmitted infection. <i>T. vaginalis</i> infection is asymptomatic in most infected men but can lead to chronic infection. The inflammatory response to chronic <i>T. vaginalis</i> infection may contribute to prostatic diseases, such as prostatitis and benign prostatic hyperplasia (BPH); however, studies on the relationship between <i>T. vaginalis</i> infection and prostate diseases are scarce. In this review, we discuss evidence from our studies on the involvement of <i>T. vaginalis</i> in the pathogenesis of prostate diseases, such as prostatitis and BPH. Studies of prostatitis have demonstrated that the attachment of <i>T. vaginalis</i> trophozoite to prostate epithelial cells (PECs) induces inflammatory cytokine production and inflammatory cell migration, leading to prostatitis. <i>T. vaginalis</i> also causes pathological changes, such as inflammatory cell infiltration, acinar changes, interstitial fibrosis, and mast cell infiltration, in prostate tissues of infected rats. Thus, <i>T. vaginalis</i> is considered an infectious agent that triggers prostatitis. Meanwhile, studies of prostatic hyperplasia revealed that mast cells activated by <i>T. vaginalis</i>-infected prostate cells secreted inflammatory mediators, such as β-hexosaminidase and tryptase, which promoted proliferation of prostate stromal cell (PSC). Moreover, interleukin-6 produced by proliferating PSCs induced the multiplication of BPH-1 epithelial cells as a result of stromal–epithelial interaction, suggesting that the proliferation of <i>T. vaginalis</i>-infected prostate cells can be induced through crosstalk with mast cells. These collective findings suggest that <i>T. vaginalis</i> contributes to the progression of prostatitis and prostatic hyperplasia by creating an inflammatory microenvironment involving PECs and PSCs. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한기생충학ㆍ열대의학회 | - |
dc.title | Inflammatory response to Trichomonas vaginalis in the pathogenesis of prostatitis and benign prostatic hyperplasia | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ryu, Jae Sook | - |
dc.identifier.doi | 10.3347/PHD.22160 | - |
dc.identifier.scopusid | 2-s2.0-85149363820 | - |
dc.identifier.wosid | 001008212100002 | - |
dc.identifier.bibliographicCitation | Parasites, Hosts and Diseases, v.61, no.1, pp.2 - 14 | - |
dc.relation.isPartOf | Parasites, Hosts and Diseases | - |
dc.citation.title | Parasites, Hosts and Diseases | - |
dc.citation.volume | 61 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 2 | - |
dc.citation.endPage | 14 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.identifier.kciid | ART002936145 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Parasitology | - |
dc.relation.journalWebOfScienceCategory | Parasitology | - |
dc.subject.keywordPlus | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | MAST-CELLS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | ETIOLOGY | - |
dc.subject.keywordPlus | LEPTIN | - |
dc.subject.keywordPlus | MICROENVIRONMENT | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | CROSSTALK | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | proliferatio | - |
dc.subject.keywordAuthor | prostatic hyperplasia | - |
dc.subject.keywordAuthor | prostatitis | - |
dc.subject.keywordAuthor | Trichomonas vaginalis | - |
dc.identifier.url | https://parahostdis.org/journal/view.php?doi=10.3347/PHD.22160 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.