Two-year clinical outcomes after discontinuation of long-term golimumab therapy in Korean patients with rheumatoid arthritis
DC Field | Value | Language |
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dc.contributor.author | Shin, Kichul | - |
dc.contributor.author | Kwon, Hyun Mi | - |
dc.contributor.author | Kim, Min Jung | - |
dc.contributor.author | Yoon, Myung Jae | - |
dc.contributor.author | Chai, Hyun Gyung | - |
dc.contributor.author | Kang, Seong-Wook | - |
dc.contributor.author | Park, Won | - |
dc.contributor.author | Park, Sung-Hwan | - |
dc.contributor.author | Suh, Chang Hee | - |
dc.contributor.author | Kim, Hyun Ah | - |
dc.contributor.author | Lee, Seung-Geun | - |
dc.contributor.author | Lee, Choong Ki | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Park, Yong-Beom | - |
dc.contributor.author | Song, Yeong Wook | - |
dc.date.accessioned | 2023-11-14T08:05:01Z | - |
dc.date.available | 2023-11-14T08:05:01Z | - |
dc.date.created | 2022-01-26 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/192096 | - |
dc.description.abstract | Background/Aims: The aim of this study was to investigate long-term post -discontinuation outcomes in patients with rheumatoid arthritis (RA) who had been treated with tumor necrosis factor-alpha inhibitors (TNF-alpha i) which was then discontinued. Methods: Sixty Korean patients with RA who participated in a 5-year GO-BEFORE and GO-FORWARD extension trials were included in this retrospective study. Golimumab was deliberately discontinued after the extension study (baseline). Patients were then followed by their rheumatologists. We reviewed their medical records for 2 years (max 28 months) following golimumab discontinuation. Patients were divided into a maintained benefit (MB) group and a loss-of-benefit (LB) group based on treatment pattern after golimumab discontinuation. The LB group included patients whose conventional disease-modifying antirheumatic drug(s) were stepped-up or added/switched (SC) and those who restarted biologic therapy (RB). Results: The mean age of patients at baseline was 56.5 years and 55 (91.7%) were females. At the end of follow-up, 23 (38.3%) patients remained in the MB group. In the LB group, 75.7% and 24.3% were assigned into SC and RB subgroups, respectively. Fifty percent of patients lost MB after 23.3 months. Demographics and clinical variables at baseline were comparable between MB and LB groups except for age, C-reactive protein level, and corticosteroid use. Restarting biologic therapy was associated with swollen joint count (adjusted hazard ratio [HR], 1.90; 95% confidence interval [CI], 1.01 to 3.55) and disease duration (adjusted HR, 1.12; 95% CI, 1.02 to 1.23) at baseline. Conclusions: Treatment strategies after discontinuing TNF-alpha i are needed to better maintain disease control and quality of life of patients with RA. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ASSOC INTERNAL MEDICINE | - |
dc.title | Two-year clinical outcomes after discontinuation of long-term golimumab therapy in Korean patients with rheumatoid arthritis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bae, Sang-Cheol | - |
dc.identifier.doi | 10.3904/kjim.2021.018 | - |
dc.identifier.scopusid | 2-s2.0-85137745885 | - |
dc.identifier.wosid | 000737497000001 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF INTERNAL MEDICINE, v.37, no.5, pp.1061 - 1069 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF INTERNAL MEDICINE | - |
dc.citation.title | KOREAN JOURNAL OF INTERNAL MEDICINE | - |
dc.citation.volume | 37 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1061 | - |
dc.citation.endPage | 1069 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Early Access | - |
dc.identifier.kciid | ART002868627 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | LOW-DISEASE-ACTIVITY | - |
dc.subject.keywordPlus | ADALIMUMAB PLUS METHOTREXATE | - |
dc.subject.keywordPlus | MONOCLONAL-ANTIBODY | - |
dc.subject.keywordPlus | NAIVE PATIENTS | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | REMISSION | - |
dc.subject.keywordPlus | MULTICENTER | - |
dc.subject.keywordPlus | MONOTHERAPY | - |
dc.subject.keywordPlus | ETANERCEPT | - |
dc.subject.keywordPlus | INFLIXIMAB | - |
dc.subject.keywordAuthor | Arthritis | - |
dc.subject.keywordAuthor | rheumatoid | - |
dc.subject.keywordAuthor | Golimumab | - |
dc.subject.keywordAuthor | Biological therapy | - |
dc.subject.keywordAuthor | Antirheumatic agents | - |
dc.identifier.url | https://www.kjim.org/journal/view.php?doi=10.3904/kjim.2021.018 | - |
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