Associations of prenatal and early childhood mercury exposure with autistic behaviors at 5 years of age: the Mothers and Children's Environmental Health (MOCEH) study
DC Field | Value | Language |
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dc.contributor.author | Ryu, Jia | - |
dc.contributor.author | Ha, Eun-Hee | - |
dc.contributor.author | Kimb, Boong-Nyun | - |
dc.contributor.author | Ha, Mina | - |
dc.contributor.author | Kim, Yangho | - |
dc.contributor.author | Park, Hyesook | - |
dc.contributor.author | Hong, Yun-Chul | - |
dc.contributor.author | Kim, Kyoung Nam | - |
dc.date.accessioned | 2023-11-14T08:49:11Z | - |
dc.date.available | 2023-11-14T08:49:11Z | - |
dc.date.created | 2023-07-07 | - |
dc.date.issued | 2017-12 | - |
dc.identifier.issn | 0048-9697 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/192402 | - |
dc.description.abstract | Background: Although mercury is an established neurotoxin, only few longitudinal studies have investigated the association between prenatal and early childhood mercury exposure and autistic behaviors. Methods: We conducted a longitudinal cohort study using an ongoing prospective birth cohort initiated in 2006, wherein blood mercury levels were measured at early and late pregnancy; in cord blood; and at 2 and 3 years of age. We analyzed 458 mother-child pairs. Autistic behaviors were assessed using the Social Responsiveness Scale (SRS) at 5 years of age. Both continuous SRS T-scores and T-scores dichotomized by a score of >= 60 or < 60 were used as outcomes. Results: The geometric mean of mercury concentrations in cord blood was 5.52 mu g/L. In adjusted models, a doubling of blood mercury levels at late pregnancy (beta= 1.84, 95% confidence interval [CI]: 0.39, 3.29), in cord blood (beta = 2.24, 95% CI: 0.22, 4.27), and at 2 years (beta = 2.12, 95% CI: 0.54, 3.70) and 3 years (beta = 2.80, 95% CI: 0.89, 4.72) of age was positively associated with the SRS T-scores. When the SRS T-scores were dichotomized, we observed positive associations with mercury levels at late pregnancy (relative risk [RR] = 1.31, 95% CI: 1.08, 1.60) and in cord blood (RR = 1.28, 95% CI: 1.01, 1.63). Conclusion: We found that blood mercury levels at late pregnancy and early childhood were associated with more autistic behaviors in children at 5 years of age. Further study on the long-term effects of mercury exposure is recommended. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Associations of prenatal and early childhood mercury exposure with autistic behaviors at 5 years of age: the Mothers and Children's Environmental Health (MOCEH) study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Kyoung Nam | - |
dc.identifier.doi | 10.1016/j.scitotenv.2017.06.227 | - |
dc.identifier.scopusid | 2-s2.0-85021405347 | - |
dc.identifier.wosid | 000408275500028 | - |
dc.identifier.bibliographicCitation | SCIENCE OF THE TOTAL ENVIRONMENT, v.605, pp.251 - 257 | - |
dc.relation.isPartOf | SCIENCE OF THE TOTAL ENVIRONMENT | - |
dc.citation.title | SCIENCE OF THE TOTAL ENVIRONMENT | - |
dc.citation.volume | 605 | - |
dc.citation.startPage | 251 | - |
dc.citation.endPage | 257 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.subject.keywordPlus | SOCIAL RESPONSIVENESS SCALE | - |
dc.subject.keywordPlus | SPECTRUM DISORDER | - |
dc.subject.keywordPlus | METHYLMERCURY EXPOSURE | - |
dc.subject.keywordPlus | BIRTH | - |
dc.subject.keywordPlus | CONSUMPTION | - |
dc.subject.keywordPlus | FETAL | - |
dc.subject.keywordPlus | NEUROTOXICITY | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | VALIDATION | - |
dc.subject.keywordPlus | TRAITS | - |
dc.subject.keywordAuthor | Autistic behavior | - |
dc.subject.keywordAuthor | Birth cohort | - |
dc.subject.keywordAuthor | Blood mercury | - |
dc.subject.keywordAuthor | Early childhood exposure | - |
dc.subject.keywordAuthor | Prenatal exposure | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0048969717316479?via%3Dihub | - |
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