Golgi Outpost Synthesis Impaired by Toxic Polyglutamine Proteins Contributes to Dendritic Pathology in Neurons
DC Field | Value | Language |
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dc.contributor.author | Chung, Chang Geon | - |
dc.contributor.author | Kwon, Min Jee | - |
dc.contributor.author | Jeon, Keun Hye | - |
dc.contributor.author | Hyeon, Do Young | - |
dc.contributor.author | Han, Myeong Hoon | - |
dc.contributor.author | Park, Jeong Hyang | - |
dc.contributor.author | Cha, In Jun | - |
dc.contributor.author | Cho, Jae Ho | - |
dc.contributor.author | Kim, Kunhyung | - |
dc.contributor.author | Rho, Sangchul | - |
dc.contributor.author | Kim, Gyu Ree | - |
dc.contributor.author | Jeong, Hyobin | - |
dc.contributor.author | Lee, Jae Won | - |
dc.contributor.author | Kim, TaeSoo | - |
dc.contributor.author | Kim, Keetae | - |
dc.contributor.author | Kim, Kwang Pyo | - |
dc.contributor.author | Ehlers, Michael D. | - |
dc.contributor.author | Hwang, Daehee | - |
dc.contributor.author | Lee, Sung Bae | - |
dc.date.accessioned | 2023-11-24T05:09:42Z | - |
dc.date.available | 2023-11-24T05:09:42Z | - |
dc.date.created | 2023-07-07 | - |
dc.date.issued | 2017-07 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/193053 | - |
dc.description.abstract | Dendrite aberration is a common feature of neurode-generative diseases caused by protein toxicity, but the underlying mechanisms remain largely elusive. Here, we show that nuclear polyglutamine (polyQ) toxicity resulted in defective terminal dendrite elongation accompanied by a loss of Golgi outposts (GOPs) and a decreased supply of plasma membrane (PM) in Drosophila class IV dendritic arborization (da) (C4 da) neurons. mRNA sequencing revealed that genes downregulated by polyQ proteins included many secretory pathway-related genes, including COPII genes regulating GOP synthesis. Transcription factor enrichment analysis identified CREB3L1/CrebA, which regulates COPII gene expression. CrebA overexpression in C4 da neurons restores the dysregulation of COPII genes, GOP synthesis, and PM supply. Chromatin immunoprecipitation (ChIP)-PCR revealed that CrebA expression is regulated by CREB-binding protein (CBP), which is sequestered by polyQ proteins. Furthermore, co-overexpression of CrebA and Rac1 synergistically restores the polyQ-induced dendrite pathology. Collectively, our results suggest that GOPs impaired by polyQ proteins contribute to dendrite pathology through the CBP-CrebA-COPII pathway. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.title | Golgi Outpost Synthesis Impaired by Toxic Polyglutamine Proteins Contributes to Dendritic Pathology in Neurons | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jeong, Hyobin | - |
dc.identifier.doi | 10.1016/j.celrep.2017.06.059 | - |
dc.identifier.scopusid | 2-s2.0-85022035025 | - |
dc.identifier.wosid | 000405198100008 | - |
dc.identifier.bibliographicCitation | CELL REPORTS, v.20, no.2, pp.356 - 369 | - |
dc.relation.isPartOf | CELL REPORTS | - |
dc.citation.title | CELL REPORTS | - |
dc.citation.volume | 20 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 356 | - |
dc.citation.endPage | 369 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | DROSOPHILA SALIVARY-GLAND | - |
dc.subject.keywordPlus | BINDING PROTEIN | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTORS | - |
dc.subject.keywordPlus | NUCLEAR INCLUSIONS | - |
dc.subject.keywordPlus | SECRETORY PATHWAY | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | TRANSPORT | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S2211124717308902?via%3Dihub | - |
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