Stability and Function of Mammalian Lethal Giant Larvae-1 Oncoprotein Are Regulated by the Scaffolding Protein RanBPM
DC Field | Value | Language |
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dc.contributor.author | Suresh, B | - |
dc.contributor.author | Ramakrishna, Suresh | - |
dc.contributor.author | Kim, YS | - |
dc.contributor.author | Kim, SM | - |
dc.contributor.author | Kim, MS | - |
dc.contributor.author | Baek, KH | - |
dc.date.accessioned | 2023-11-24T05:21:19Z | - |
dc.date.available | 2023-11-24T05:21:19Z | - |
dc.date.created | 2023-05-30 | - |
dc.date.issued | 2010-11 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/193111 | - |
dc.description.abstract | The evolutionarily conserved lethal giant larvae (Lgl) tumor suppressor gene has an essential role in establishing apical-basal cell polarity, cell proliferation, differentiation, and tissue organization. However, the precise molecular mechanism by which the Lgl carries out its function remains obscure. In the current study, we have identified Ran-binding protein M (RanBPM) as a novel binding partner of Mgl-1, a mammalian homolog of Drosophila tumor suppressor protein lethal (2) giant larvae (L(2)gl) by yeast two-hybrid screening. RanBPM seems to act as a scaffolding protein with a modulatory function with respect to Mgl-1. The Mgl-1 and RanBPM association was confirmed by co-immunoprecipitation and GST pull-down experiments. Additionally, expression of RanBPM resulted in inhibition of Mgl-1 degradation, and thereby extended the half-life of Mgl-1. Furthermore, the ability of Mgl-1 activity in cell migration and colony formation assay was enhanced by RanBPM. Taken together, our findings reveal that RanBPM plays a novel role in regulating Mgl-1 stability and contributes to its biological function as a tumor suppressor. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.title | Stability and Function of Mammalian Lethal Giant Larvae-1 Oncoprotein Are Regulated by the Scaffolding Protein RanBPM | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ramakrishna, Suresh | - |
dc.identifier.doi | 10.1074/jbc.M110.156836 | - |
dc.identifier.scopusid | 2-s2.0-78149250369 | - |
dc.identifier.wosid | 000283845300012 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.285, pp.35340 - 35349 | - |
dc.relation.isPartOf | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.title | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 285 | - |
dc.citation.startPage | 35340 | - |
dc.citation.endPage | 35349 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR PROTEINS | - |
dc.subject.keywordPlus | BINDING-PROTEIN | - |
dc.subject.keywordPlus | CELL POLARITY | - |
dc.subject.keywordPlus | CYTOSKELETAL PROTEIN | - |
dc.subject.keywordPlus | INTERACTING PROTEIN | - |
dc.subject.keywordPlus | NUCLEAR-PROTEIN | - |
dc.subject.keywordPlus | HUMAN HOMOLOG | - |
dc.subject.keywordPlus | GENE L(2)GL | - |
dc.subject.keywordPlus | DROSOPHILA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0021925820468747?via%3Dihub | - |
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