Targeted exome sequencing of Korean triple-negative breast cancer reveals homozygous deletions associated with poor prognosis of adjuvant chemotherapy-treated patients
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Hae Min | - |
dc.contributor.author | Kim, Ryong Nam | - |
dc.contributor.author | Kwon, Mi Jeong | - |
dc.contributor.author | Oh, Ensel | - |
dc.contributor.author | Han, Jinil | - |
dc.contributor.author | Lee, Se Kyung | - |
dc.contributor.author | Choi, Jong-Sun | - |
dc.contributor.author | Park, Sara | - |
dc.contributor.author | Nam, Seok Jin | - |
dc.contributor.author | Gong, Gyung Yup | - |
dc.contributor.author | Nam, Jin Wu | - |
dc.contributor.author | Choi, Doo Ho | - |
dc.contributor.author | Lee, Hannah | - |
dc.contributor.author | Nam, Byung-Ho | - |
dc.contributor.author | Choi, Yoon-La | - |
dc.contributor.author | Shin, Young Kee | - |
dc.date.accessioned | 2021-08-02T14:51:19Z | - |
dc.date.available | 2021-08-02T14:51:19Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017-09 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/19430 | - |
dc.description.abstract | Triple-negative breast cancer is characterized by the absence of estrogen and progesterone receptors and human epidermal growth factor receptor 2, and is associated with a poorer outcome than other subtypes of breast cancer. Moreover, there are no accurate prognostic genes or effective therapeutic targets, thereby necessitating continued intensive investigation. This study analyzed the genetic mutation landscape in 70 patients with triple-negative breast cancer by targeted exome sequencing of tumor and matched normal samples. Sequencing showed that more than 50% of these patients had deleterious mutations and homozygous deletions of DNA repair genes, such as ATM, BRCA1, BRCA2, WRN, and CHEK2. These findings suggested that a large number of patients with triple-negative breast cancer have impaired DNA repair function and that therefore a poly ADP-ribose polymerase inhibitor may be an effective drug in the treatment of this disease. Notably, homozygous deletion of three genes, EPHA5, MITF, and ACSL3, was significantly associated with an increased risk of recurrence or distant metastasis in adjuvant chemotherapy-treated patients. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | IMPACT JOURNALS LLC | - |
dc.title | Targeted exome sequencing of Korean triple-negative breast cancer reveals homozygous deletions associated with poor prognosis of adjuvant chemotherapy-treated patients | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Nam, Jin Wu | - |
dc.identifier.doi | 10.18632/oncotarget.18618 | - |
dc.identifier.scopusid | 2-s2.0-85028757486 | - |
dc.identifier.wosid | 000409254200063 | - |
dc.identifier.bibliographicCitation | ONCOTARGET, v.8, no.37, pp.61538 - 61550 | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.citation.title | ONCOTARGET | - |
dc.citation.volume | 8 | - |
dc.citation.number | 37 | - |
dc.citation.startPage | 61538 | - |
dc.citation.endPage | 61550 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | BRCA2 | - |
dc.subject.keywordPlus | HETEROGENEITY | - |
dc.subject.keywordPlus | MULTIPOTENCY | - |
dc.subject.keywordPlus | TUMORS | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordAuthor | triple-negative breast cancer | - |
dc.subject.keywordAuthor | targeted exome sequencing | - |
dc.subject.keywordAuthor | single nucleotide variant | - |
dc.subject.keywordAuthor | copy number variation | - |
dc.subject.keywordAuthor | DNA repair pathway | - |
dc.identifier.url | https://www.oncotarget.com/article/18618/text/ | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.