Patterns of Early Neocortical Amyloid- b Accumulation: A PET Population-Based Study

Abstract

The widespread deposition of amyloid- P (A P ) plaques in late -stage Alzheimer disease is well defined and confirmed by in vivo PET. However, there are discrepancies between which regions contribute to the earliest topographic A P deposition within the neocortex. Methods: This study investigated A P signals in the perithreshold SUV ratio range using Pittsburgh compound B (PiB) PET in a population -based study cross -sectionally and longitudinally. PiB PET scans from 1,088 participants determined the early patterns of PiB loading in the neocortex. Results: Early -stage A P loading is seen first in the temporal, cingulate, and occipital regions. Regional early deposition patterns are similar in both apolipoprotein s 4 carriers and noncarriers. Clustering analysis shows groups with different patterns of early amyloid deposition. Conclusion: These findings of initial A P deposition patterns may be of significance for diagnostics and understanding the development of Alzheimer disease phenotypes.