Fatal lactic acidosis in hepatitis B virus-associated decompensated cirrhosis treated with tenofovir A case report
DC Field | Value | Language |
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dc.contributor.author | Jung, Tae Yang | - |
dc.contributor.author | Jun, Dae Won | - |
dc.contributor.author | Lee, Kang Nyeong | - |
dc.contributor.author | Lee, Hang Lak | - |
dc.contributor.author | Lee, Oh Young | - |
dc.contributor.author | Yoon, Byung Chul | - |
dc.contributor.author | Choi, Ho Soon | - |
dc.date.accessioned | 2021-08-02T14:54:32Z | - |
dc.date.available | 2021-08-02T14:54:32Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017-06 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/19664 | - |
dc.description.abstract | Rationale: Recently tenofovir disoproxil fumarate (TDF) has been widely used as a first-line therapy for chronic hepatitis B (CHB) infection. Although TDF demonstrates successful viral suppression, the possibility of renal failure and lactic acidosis has been proposed with TDF administration, especially in human immunodeficiency virus co-infected patients. However, TDF induced lactic acidosis has never been reported in CHB mono-infected patients. Patient concerns: A 59-year-old man received TDF for hepatitis B associated with cirrhosis. After ten days of TDF administration, nausea, vomiting and abdominal pain developed. High anion gap acidosis with elevated lactate level (pH 7.341, pCO₂ 29.7 mmHg, HCO₃-15.6mmHg, lactate 3.2mmol/L, anion gap 15.4 mEq/L) was developed. Diagnosis: With no infection, normal diagnostic paracentesis, and urinalysis together with high anion gap and increased blood lactate levels suggested lactic acidosis. Interventions: TDF was stopped, and haemodialysis was performed to control lactic acidosis. Outcomes: Although stopping TDF instantly and treating lactic acidosis using hemodialysis, the patient died. Lessons: Although, Fatal lactic acidosis is very rare in TDF patient, however, decompensated cirrhotic patients should be closely observed to keep the possibility of lactic acidosis in mind. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.title | Fatal lactic acidosis in hepatitis B virus-associated decompensated cirrhosis treated with tenofovir A case report | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jun, Dae Won | - |
dc.contributor.affiliatedAuthor | Lee, Kang Nyeong | - |
dc.contributor.affiliatedAuthor | Lee, Hang Lak | - |
dc.contributor.affiliatedAuthor | Lee, Oh Young | - |
dc.contributor.affiliatedAuthor | Yoon, Byung Chul | - |
dc.contributor.affiliatedAuthor | Choi, Ho Soon | - |
dc.identifier.doi | 10.1097/MD.0000000000007133 | - |
dc.identifier.scopusid | 2-s2.0-85021775065 | - |
dc.identifier.wosid | 000404116900016 | - |
dc.identifier.bibliographicCitation | MEDICINE, v.96, no.25 | - |
dc.relation.isPartOf | MEDICINE | - |
dc.citation.title | MEDICINE | - |
dc.citation.volume | 96 | - |
dc.citation.number | 25 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | HYPER-CHLOREMIC ACIDOSIS | - |
dc.subject.keywordPlus | SPIRONOLACTONE | - |
dc.subject.keywordPlus | NUCLEOSIDE | - |
dc.subject.keywordPlus | DIDANOSINE | - |
dc.subject.keywordAuthor | HBV | - |
dc.subject.keywordAuthor | lactic acidosis | - |
dc.subject.keywordAuthor | tenofovir disoproxil fumarate | - |
dc.identifier.url | https://journals.lww.com/md-journal/Fulltext/2017/06230/Fatal_lactic_acidosis_in_hepatitis_B.16.aspx | - |
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