Vitamin D deficiency in non-alcoholic fatty liver disease: The chicken or the egg?
DC Field | Value | Language |
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dc.contributor.author | Lee, Seung Min | - |
dc.contributor.author | Jun, Dae Won | - |
dc.contributor.author | Cho, Yong Kyun | - |
dc.contributor.author | Jang, Ki Seol | - |
dc.date.accessioned | 2021-08-02T15:50:59Z | - |
dc.date.available | 2021-08-02T15:50:59Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017-02 | - |
dc.identifier.issn | 0261-5614 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/21178 | - |
dc.description.abstract | Background & aims: Serum vitamin D concentration is reduced in patients with non-alcoholic fatty liver disease (NAFLD). Although the mechanism of vitamin D deficiency in liver disease is not fully understood, a few reports have suggested the beneficial effects of vitamin D supplements. The present study investigated changes in serum 25-hydroxy vitamin D level and clinical parameters after total calorie restriction with vitamin D intake reduction in NAFLD patients. Methods: Newly diagnosed NAFLD patients with elevated aminotransferase levels were chosen for a calorie restriction and weight-reduction program. A total of 82 patients received nutritional education from nutritionists every 2 weeks for 2 months. Serum 25-hydroxy vitamin D level, amount of vitamin D intake, and physical activity were thoroughly investigated. Results: The mean serum 25-hydroxy vitamin D concentration was 13.0 ng/ml. Twenty-nine patients (35.4%) had severe vitamin D deficiency. Patients with a 25-hydroxy vitamin D concentration <10 ng/ml had an increased risk of abdominal obesity (72.4% vs. 47.2%, P = 0.023) and a higher prevalence of metabolic syndrome (69% vs. 42.2%, P = 0.015) compared with patients with 25-hydroxy vitamin D levels >10 ng/ml. Although total energy and vitamin D intake were reduced during the program, serum 25-hydroxy vitamin D levels increased in patients with NAFLD (P < 0.001). Liver enzymes and metabolic parameters also improved, even as vitamin D intake decreased. Serum vitamin D concentration increased with body weight and intrahepatic fat reduction, independent of decreases in vitamin D intake. Conclusions: Weight loss per increased serum vitamin D level without vitamin D supplementation and improved metabolic parameters in NAFLD. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | CHURCHILL LIVINGSTONE | - |
dc.title | Vitamin D deficiency in non-alcoholic fatty liver disease: The chicken or the egg? | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jun, Dae Won | - |
dc.identifier.doi | 10.1016/j.clnu.2015.10.017 | - |
dc.identifier.scopusid | 2-s2.0-84947996830 | - |
dc.identifier.wosid | 000397833800020 | - |
dc.identifier.bibliographicCitation | Clinical Nutrition, v.36, no.1, pp.191 - 197 | - |
dc.relation.isPartOf | Clinical Nutrition | - |
dc.citation.title | Clinical Nutrition | - |
dc.citation.volume | 36 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 191 | - |
dc.citation.endPage | 197 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | D INADEQUACY | - |
dc.subject.keywordPlus | WEIGHT-LOSS | - |
dc.subject.keywordPlus | OSTEOPOROSIS | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | ADULTS | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordAuthor | Non-alcoholic fatty liver disease | - |
dc.subject.keywordAuthor | Vitamin D | - |
dc.subject.keywordAuthor | Sunlight exposure | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S026156141500271X?via%3Dihub | - |
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