Recent trends in inhaled corticosteroid prescriptions and its impact on COPD management: an analysis of the KOLD/KOCOSS cohorts
DC Field | Value | Language |
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dc.contributor.author | Lee, Se Hee | - |
dc.contributor.author | Lee, Ji-Hyun | - |
dc.contributor.author | Il Yoon, Ho | - |
dc.contributor.author | Park, Hye Yun | - |
dc.contributor.author | Kim, Tae-Hyung | - |
dc.contributor.author | Yoo, Kwang Ha | - |
dc.contributor.author | Oh, Yeon-Mok | - |
dc.contributor.author | Jung, Ki Suk | - |
dc.contributor.author | Lee, Sang-Do | - |
dc.contributor.author | Lee, Sei Won | - |
dc.date.accessioned | 2021-07-30T04:55:07Z | - |
dc.date.available | 2021-07-30T04:55:07Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2019-09 | - |
dc.identifier.issn | 0903-1936 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/2152 | - |
dc.description.abstract | Background: This real-world cohort study was performed in chronic obstructive pulmonary disease (COPD) patients to evaluate the status of inhaled corticosteroid (ICS) prescriptions following the 2017 revision of the GOLD guidelines. Methods: A total of 1144 patients from KOLD and KOCOSS cohorts, whose final follow-up visits were between 2017 and 2018, were analyzed. Features supporting ICS usage were: a history of asthma, blood eosinophils ≥300 cells/µl, or ≥2 exacerbations in the previous year. Among baseline ICS users, we compared annual total and severe exacerbation rates, based on ICS continuation or withdrawal. Results: ICS-containing regimens were prescribed for 46.3% of patients at baseline; this decreased to 38.8% in 2017, and long-acting dual bronchodilators were widely used instead. Among ICS users in 2017, 47.5% did not exhibit features supporting ICS usage. ICS was withdrawn in 77 (16.1%) patients during the study period. Annual exacerbation rates were similar between ICS withdrawal and ICS continued groups (0.48 vs. 0.47, p=0.84); however, the ICS withdrawal group exhibited a significantly higher severe exacerbation rate (0.22 vs. 0.12, p=0.03). The proportion of patients with asthma and the baseline annual exacerbation rate were greater in the ICS withdrawal group than in the ICS continued group (56.6% vs. 41%, p=0.01; 0.79 vs. 0.53, p<0.001). Conclusions: Prescriptions of ICS in COPD patients decreased with increased use of long-acting dual bronchodilators. ICS withdrawal might impact severe exacerbation; therefore it should be decided with consideration of potential risk and benefits of ICS based on patients’ characteristics. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | EUROPEAN RESPIRATORY SOC JOURNALS LTD | - |
dc.title | Recent trends in inhaled corticosteroid prescriptions and its impact on COPD management: an analysis of the KOLD/KOCOSS cohorts | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae-Hyung | - |
dc.identifier.doi | 10.1183/13993003.congress-2019.PA2506 | - |
dc.identifier.wosid | 000507372403033 | - |
dc.identifier.bibliographicCitation | EUROPEAN RESPIRATORY JOURNAL, v.54 | - |
dc.relation.isPartOf | EUROPEAN RESPIRATORY JOURNAL | - |
dc.citation.title | EUROPEAN RESPIRATORY JOURNAL | - |
dc.citation.volume | 54 | - |
dc.type.rims | ART | - |
dc.type.docType | Meeting Abstract | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordAuthor | COPD - management | - |
dc.subject.keywordAuthor | Bronchodilators | - |
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