CpG Oligodeoxynucleotide Inhibits Cockroach-Induced Asthma via Induction of IFN-γ+ Th1 Cells or Foxp3+ Regulatory T Cells in the Lung
DC Field | Value | Language |
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dc.contributor.author | Kim, Do-Hyun | - |
dc.contributor.author | Sohn, Jung-Ho | - |
dc.contributor.author | Park, Hong-Jai | - |
dc.contributor.author | Lee, Jae-Hyun | - |
dc.contributor.author | Park, Jung-Won | - |
dc.contributor.author | Choi, Je-Min | - |
dc.date.accessioned | 2021-08-02T16:53:21Z | - |
dc.date.available | 2021-08-02T16:53:21Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2016-05 | - |
dc.identifier.issn | 2092-7355 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/23102 | - |
dc.description.abstract | Purpose: CpG oligodeoxynucleotide (CpG-ODN), a TLR9 agonist, activates innate immunity and induces Th1 response. Although the immune modulatory effect of CpG-ODN has been extensively studied, its function in cockroach extract-induced allergic asthma has not been studied. Here, we investigated the inhibitory function of CpG-ODN in cockroach extract-induced asthma in mice with different treatment schemes. Methods: Scheme 1: BALB/C mice were intra-nasally co-administered by cockroach extract and CpG-ODN twice a week for 3 weeks; Scheme 2: The mice were intra-nasally pre-treated with CpG-ODN at day 0 and cockroach allergen challenge was performed from day 3 as in scheme 1. Scheme 3: Cockroach allergen challenge was performed as in scheme 1 and CpG-ODN was post-treated at day 21. Then, BAL cell count, flow cytometric analysis of alveolar macrophages, regulatory T cells, and lung tissue histology, Th1 and Th2 cytokines, serum IgE, cockroach specific IgE, IgG1/IgG2a ratio, and airway hyper-responsiveness were evaluated. Results: Mice with repeated intra-nasal exposure to CpG-ODN showed a dramatic decrease in eosinophilic inflammation, goblet cell hyperplasia, and airway hyper-responsiveness with reduction of IL-13, IL-5, and serum IgE, cockroach specific IgE and IgG1/IgG2a ratio. This inhibitory function might be related to the up-regulation of IL-10 and CD4(+)Foxp3(+) regulatory T cells in the lung. Interestingly, one-time challenge of CpG-ODN either prior or posterior to cockroach extract exposure could modulate airway inflammation and hyper-responsiveness via increase of Th1 response. Conclusions: Collectively, our data suggest that CpG-ODN treatment modulates Th2 inflammation in the lung by induction of regulatory T cells or Th1 response in a cockroach-induced asthma model. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY | - |
dc.title | CpG Oligodeoxynucleotide Inhibits Cockroach-Induced Asthma via Induction of IFN-γ+ Th1 Cells or Foxp3+ Regulatory T Cells in the Lung | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Je-Min | - |
dc.identifier.doi | 10.4168/aair.2016.8.3.264 | - |
dc.identifier.scopusid | 2-s2.0-84959885845 | - |
dc.identifier.wosid | 000375351000012 | - |
dc.identifier.bibliographicCitation | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, v.8, no.3, pp.264 - 275 | - |
dc.relation.isPartOf | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | - |
dc.citation.title | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | - |
dc.citation.volume | 8 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 264 | - |
dc.citation.endPage | 275 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002100531 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | PLASMACYTOID DENDRITIC CELLS | - |
dc.subject.keywordPlus | HOUSE-DUST MITE | - |
dc.subject.keywordPlus | BACTERIAL-DNA | - |
dc.subject.keywordPlus | MURINE MODEL | - |
dc.subject.keywordPlus | AIRWAY INFLAMMATION | - |
dc.subject.keywordPlus | IFN-GAMMA | - |
dc.subject.keywordPlus | GERMAN-COCKROACH | - |
dc.subject.keywordPlus | BRONCHIAL-ASTHMA | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | ALLERGEN | - |
dc.subject.keywordAuthor | CpG-ODN | - |
dc.subject.keywordAuthor | cockroach allergen | - |
dc.subject.keywordAuthor | Th2 inflammation | - |
dc.subject.keywordAuthor | immune modulation | - |
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