Association between anti-Porphyromonas gingivalis antibody, anti-citrullinated protein antibodies, and rheumatoid arthritis A meta-analysis
- Authors
- Bae, S. -C.; Lee, Y. H.
- Issue Date
- Aug-2018
- Publisher
- SPRINGER HEIDELBERG
- Keywords
- Anti-P. gingivalis antibody; Anti-citrullinated protein antibodies; Rheumatoid arthritis
- Citation
- ZEITSCHRIFT FUR RHEUMATOLOGIE, v.77, no.6, pp.522 - 532
- Indexed
- SCIE
SCOPUS
- Journal Title
- ZEITSCHRIFT FUR RHEUMATOLOGIE
- Volume
- 77
- Number
- 6
- Start Page
- 522
- End Page
- 532
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/2320
- DOI
- 10.1007/s00393-017-0328-y
- ISSN
- 0340-1855
- Abstract
- Objective
The aim of this study was to determine the relationship between anti-Porphyromonas gingivalis (anti-P. gingivalis) antibody levels and rheumatoid arthritis (RA) and its correlation with anti-citrullinated protein antibodies (ACPA).
Methods
We performed a meta-analysis of studies comparing (a) anti-P. gingivalis antibody levels in RA patients and healthy controls and (b) the correlation coefficients between the anti-P. gingivalis antibody levels and ACPA in RA patients.
Results
The study included 14 articles with 3829 RA patients and 1239 controls. Our meta-analysis showed that anti-P. gingivalis antibody levels were significantly higher in the RA group than in the control group (standardized mean difference [SMD] = 0.630, 95% CI = 0.272–0.989, p = 0.001). Subgroup analysis revealed that RA patients had significantly elevated anti-P. gingivalis antibody levels compared with healthy controls, but not compared with the non-RA control group and also not between different sample sizes. Anti-P. gingivalis antibody levels were significantly higher in the RA group than in the control group in the age-/sex-matched population, but not in the unmatched population. Anti-P. gingivalis antibody levels were significantly higher in the ACPA-positive group than in the ACPA-negative group (SMD = 0.322, 95% CI = 0.164–0.480, p = 6.4 × 10−5). Meta-analysis of the correlation coefficients showed a significant positive correlation between anti-P. gingivalis antibody levels and ACPA (correlation coefficient = 0.147, 95% CI = 0.033–0.258, p = 0.012).
Conclusion
Our meta-analysis demonstrated that anti-P. gingivalis antibody levels were significantly higher in patients with RA and they were positively correlated with ACPA.
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