Genetic variants in systemic lupus erythematosus susceptibility loci, XKR6 and GLT1D1 are associated with childhood-onset SLE in a Korean cohort
DC Field | Value | Language |
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dc.contributor.author | Bin Joo, Young | - |
dc.contributor.author | Lim, Jiwoo | - |
dc.contributor.author | Tsao, Betty P. | - |
dc.contributor.author | Nath, Swapan K. | - |
dc.contributor.author | Kim, Kwangwoo | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.date.accessioned | 2021-07-30T04:56:35Z | - |
dc.date.available | 2021-07-30T04:56:35Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2018-07 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/2345 | - |
dc.description.abstract | Impact of genetic variants on the age of systemic lupus erythematosus (SLE) onset was not fully understood. We investigated a cumulative effect of SLE-risk variants on the age of SLE onset and scanned genome-wide SNPs to search for new risk loci of childhood-onset SLE (cSLE). We analyzed 781 Korean single-center SLE subjects who previously genotyped by both Immunochip and genome-wide SNP arrays. Individual genetic risk scores (GRS) from well-validated SLE susceptibility loci were calculated and tested for their association with cSLE (<16 years at onset). Single-variant association tests were performed using a multivariable logistic regression adjusting for population stratification. GRS from SLE susceptibility loci was significantly higher in cSLE than aSLE (p = 1.23 x 10⁻³). Two SNPs, rs7460469 in XKR6 (p = 1.26 x 10⁻⁸, OR = 5.58) and rs7300146 in GLT1D1 p = 1.49 x 10⁻⁸, OR = 2.85), showed the most significant associations with cSLE. The model consisting of GRS of SLE and two newly identified loci showed an area under curve (AUC) of 0.71 in a receiver operating characteristics (ROC) curve for prediction of cSLE. In conclusion, cSLE is associated with a high cumulative SLE-risk effect and two novel SNPs rs7460469 and rs7300146, providing the first predictive model for cSLE in Koreans. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Genetic variants in systemic lupus erythematosus susceptibility loci, XKR6 and GLT1D1 are associated with childhood-onset SLE in a Korean cohort | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bae, Sang-Cheol | - |
dc.identifier.doi | 10.1038/s41598-018-28128-z | - |
dc.identifier.scopusid | 2-s2.0-85049400957 | - |
dc.identifier.wosid | 000436955000017 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.8 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | GENOME-WIDE ASSOCIATION | - |
dc.subject.keywordPlus | CLINICAL-MANIFESTATIONS | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | POPULATIONS | - |
dc.subject.keywordPlus | ENDOSOMES | - |
dc.subject.keywordPlus | RISK | - |
dc.identifier.url | https://www.nature.com/articles/s41598-018-28128-z | - |
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