Association between the functional PTPN22 G788A (R263Q) polymorphism and susceptibility to autoimmune diseases: A meta-analysisopen access
- Authors
- Bae, Sang-Cheol; Lee, Young Ho
- Issue Date
- Apr-2018
- Publisher
- C M B Association
- Keywords
- PTPN22; Autoimmune diseases; Meta-analysis
- Citation
- Cellular and Molecular Biology, v.64, no.5, pp.46 - 51
- Indexed
- SCIE
SCOPUS
- Journal Title
- Cellular and Molecular Biology
- Volume
- 64
- Number
- 5
- Start Page
- 46
- End Page
- 51
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/2391
- DOI
- 10.14715/cmb/2018.64.5.7
- ISSN
- 0145-5680
- Abstract
- This study explored whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) G788A(R263Q) polymorphism is associated with susceptibility to autoimmune diseases. A meta-analysis was conducted using 23 comparative studies with a total of 16,719 patients and 17,783 controls. The meta analysis showed an association between the A allele of the PTPN22 C1788A polymorphism and decreased risk of autoimmune diseases in all subjects (p < 0.001). Analysis after stratification by ethnicity indicated that the PTPN22 788A allele was significantly associated with autoimmune diseases in Europeans (p < 0.001) hut not in Latin Americans. Meta-analysis by autoimmune disease type showed a significant negative association between the PTPN22 788A allele and systemic lupus erythematous (SLE) (p = 001), rheumatoid arthritis (RA) (p = 0.008), ulcerative colitis (UC) (p = 0.016), but not Crohn's disease (CD). A single study for each showed no association between the PTPN22 788A allele and systemic sclerosis, giant cell arteritis, Henoch-schonlein purpura, uveitis, and Grave's disease. This meta-analysis demonstrates that the PTPN22 0788A polymorphism confers protection against SLE, RA, and UC, supporting evidence of association of the PTPN22 gene with a subgroup of autoimmune diseases.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의과대학 > 서울 내과학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/2391)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.