Late-onset systemic lupus erythematosus: Is it "mild lupus"?
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sohn, I. W. | - |
dc.contributor.author | Joo, Y. B. | - |
dc.contributor.author | Won, S. | - |
dc.contributor.author | Bae, S. C. | - |
dc.date.accessioned | 2021-07-30T04:58:19Z | - |
dc.date.available | 2021-07-30T04:58:19Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2018-02 | - |
dc.identifier.issn | 0961-2033 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/2418 | - |
dc.description.abstract | Objective The objective of this paper is to investigate the clinical characteristics and prognosis of patients with late-onset systemic lupus erythematosus (SLE) using a prospective observational cohort. Methods Late-onset SLE (≥50 years old) was compared with adult-onset SLE (≥18 and <50 years old) using 1997 ACR classification criteria for SLE, autoantibodies, disease activity measured by Adjusted Mean SLE Disease Activity Index (AMS), and damage measured by Systemic Lupus International Collaborating Clinics/ACR Damage Index (SDI). The standardized mortality ratio (SMR) was calculated. Results A total of 917 patients with SLE were enrolled. The mean number of cumulative ACR criteria in late-onset SLE (n = 32, 3.5%) was lower than that in adult-onset SLE (4.6 ± 1.2 vs. 5.5 ± 1.4, p < 0.05). The percentage of patients with low complement was lower in late-onset SLE than adult-onset SLE (p < 0.05). AMS was also lower in late-onset SLE (2.7 ± 2.1 vs. 4.3 ± 2.6, p < 0.01), but SDI was similar between the two groups (50% vs. 43.4%, p = 0.58). The SMR of late-onset SLE was 1.58 (95% CI 0.58–3.43), while the SMR of adult-onset SLE was 3.34 (2.34–4.63). Conclusion Compared with adult-onset SLE, late-onset SLE has a lower number of ACR criteria and lower disease activity. Organ damage is not different, but prognosis and mortality are more favorable. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.title | Late-onset systemic lupus erythematosus: Is it "mild lupus"? | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bae, S. C. | - |
dc.identifier.doi | 10.1177/0961203317716789 | - |
dc.identifier.scopusid | 2-s2.0-85039759893 | - |
dc.identifier.wosid | 000418862100008 | - |
dc.identifier.bibliographicCitation | LUPUS, v.27, no.2, pp.235 - 242 | - |
dc.relation.isPartOf | LUPUS | - |
dc.citation.title | LUPUS | - |
dc.citation.volume | 27 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 235 | - |
dc.citation.endPage | 242 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | LONG-TERM SURVIVAL | - |
dc.subject.keywordPlus | CLINICAL-FEATURES | - |
dc.subject.keywordPlus | DISEASE-ACTIVITY | - |
dc.subject.keywordPlus | KOREAN PATIENTS | - |
dc.subject.keywordPlus | SOCIOECONOMIC-STATUS | - |
dc.subject.keywordPlus | CHILDHOOD-ONSET | - |
dc.subject.keywordPlus | ORGAN DAMAGE | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | ADULT-ONSET | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordAuthor | Systemic lupus erythematosus | - |
dc.subject.keywordAuthor | late-onset | - |
dc.subject.keywordAuthor | prognosis | - |
dc.identifier.url | https://journals.sagepub.com/doi/10.1177/0961203317716789 | - |
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