FCGR2A, FCGR3A, FCGR3B polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Y. H. | - |
dc.contributor.author | Bae, S. -C. | - |
dc.contributor.author | Song, G. G. | - |
dc.date.accessioned | 2021-08-02T17:54:20Z | - |
dc.date.available | 2021-08-02T17:54:20Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2015-09 | - |
dc.identifier.issn | 0392-856X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/24873 | - |
dc.description.abstract | Objective The aim of this study is to explore whether Fc gamma receptor (FCGR) polymorphisms are associated with the susceptibility to rheumatoid arthritis (RA). Methods We conducted a meta-analysis on the association between FCGR2A H131R (rs1801274), FCGR3A F158V (rs396991), and FCGR3B NA1INA2 polymorphisms and RA susceptibility Results A total of seventeen studies reported in fourteen articles (4,418 patients with RA and 3,560 controls) were considered in our meta-analysis. In all of the study subjects, meta-analysis indicated an association between RA and FCGR2A R allele (OR=0.877, 95% CI=0.792-0.971, p=0.011). Stratification by ethnicity indicated an association between FCGR2A R allele and RA in Europeans (OR=0.816, 95% CI=0.687-0.968, p=0.020), but not in East Asians (OR=0.900, 95% CI=0.778-1.040, p=0.154). Meta-analysis revealed an association between RA and FCGR3A VV vs. FF genotype in all the study subjects (OR=1.210, 95% CI=1.067-1.479, p=0.006). Stratification by ethnicity indicated an association between FCGR3A VV genotype and RA compared to FF genotype in Europeans (OR=1.350, 95% CI=1.107-1.646, p=0.003), but not in East Asians and South Asians. No association was observed between RA and FCGR3B polymorphisms on performing the meta-analysis. Conclusion Although no relationship was found between the FCGR3B polymorphism and RA susceptibility, FCGR2A and FCGR3A polymorphisms were found to be associated With RA in Europeans, but not in Asians. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | CLINICAL & EXPER RHEUMATOLOGY | - |
dc.title | FCGR2A, FCGR3A, FCGR3B polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bae, S. -C. | - |
dc.identifier.scopusid | 2-s2.0-84944415695 | - |
dc.identifier.wosid | 000364357000008 | - |
dc.identifier.bibliographicCitation | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, v.33, no.5, pp.647 - 654 | - |
dc.relation.isPartOf | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | - |
dc.citation.title | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | - |
dc.citation.volume | 33 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 647 | - |
dc.citation.endPage | 654 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | FC-GAMMA-RIIIA | - |
dc.subject.keywordPlus | RECEPTOR-TYPE IIIA | - |
dc.subject.keywordPlus | IMMUNOGLOBULIN-G | - |
dc.subject.keywordPlus | FUNCTIONAL VARIANT | - |
dc.subject.keywordPlus | GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | JAPANESE | - |
dc.subject.keywordPlus | IGG | - |
dc.subject.keywordPlus | IIB | - |
dc.subject.keywordPlus | SEVERITY | - |
dc.subject.keywordAuthor | FCG receptor | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | rheumatoid arthritis | - |
dc.subject.keywordAuthor | meta-analysis | - |
dc.identifier.url | https://www.clinexprheumatol.org/abstract.asp?a=8801 | - |
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