DC-Based Immunotherapy Combined with Low-Dose Methotrexate Effective in the Treatment of Advanced CIA in Mice
DC Field | Value | Language |
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dc.contributor.author | Park, Jun-Eui | - |
dc.contributor.author | Jang, Jinah | - |
dc.contributor.author | Choi, Ji-Hye | - |
dc.contributor.author | Kang, Mi-sun | - |
dc.contributor.author | Woo, Yun-Ju | - |
dc.contributor.author | Seong, Young-Rim | - |
dc.contributor.author | Choi, Chan-Bum | - |
dc.contributor.author | Lee, Hye-Soon | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Bae, Yong-Soo | - |
dc.date.accessioned | 2021-08-02T17:55:48Z | - |
dc.date.available | 2021-08-02T17:55:48Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 2314-8861 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/24956 | - |
dc.description.abstract | We have previously demonstrated that semimature dendritic cell- (smDC-) based immunotherapy is effective for the treatment of collagen-induced arthritis (CIA) prior to disease onset. In the present study, we examined the efficacy of combination therapy with smDCs and methotrexate (MTX) in advanced CIA with a score of 2-3. Combination therapy with low-dose MTX and type II collagen- (CII-) pulsed smDCs (CII-smDCs) was more effective in inhibiting disease progression than high or low-dose MTX alone or a combination of high dose MTX and CII-smDCs. The effect of CII-smDCs alone was also comparable to the combination therapy. CD4(+)Foxp3(+) Treg populations and IL-10 secretion markedly increased, and CII-specific autoreactive T cells decreased in mice treated with CII-smDCs alone or in combination with MTX. Combination therapy reduced the secretion of interferon-gamma (IFN-gamma) and IL-17 with little influence on the IL-4 secretion in the mixed leukocyte reaction. These results imply that the combination therapy with low-dose MTX and smDCs is effective in controlling advanced CIA by enhancing Treg population and suppresses antigen-specific Th1/Th17 immunity, rather than initiating Th1 to Th2 immune deviation. Our findings provide a better understanding of the DC therapy in combination with MTX for the treatment of patients with rheumatoid arthritis (RA). | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | HINDAWI LTD | - |
dc.title | DC-Based Immunotherapy Combined with Low-Dose Methotrexate Effective in the Treatment of Advanced CIA in Mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Chan-Bum | - |
dc.contributor.affiliatedAuthor | Lee, Hye-Soon | - |
dc.contributor.affiliatedAuthor | Bae, Sang-Cheol | - |
dc.identifier.doi | 10.1155/2015/834085 | - |
dc.identifier.scopusid | 2-s2.0-84937019533 | - |
dc.identifier.wosid | 000357790800001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY RESEARCH, v.2015, pp.1 - 15 | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY RESEARCH | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY RESEARCH | - |
dc.citation.volume | 2015 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 15 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | COLLAGEN-INDUCED ARTHRITIS | - |
dc.subject.keywordPlus | TOLEROGENIC DENDRITIC CELLS | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | NECROSIS FACTOR | - |
dc.subject.keywordPlus | EXPRESS IL-4 | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | TOLERANCE | - |
dc.subject.keywordPlus | INDUCTION | - |
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