Anti-C1q antibodies in systemic lupus erythematosus
DC Field | Value | Language |
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dc.contributor.author | Orbai, A-M | - |
dc.contributor.author | Truedsson, L. | - |
dc.contributor.author | Sturfelt, G. | - |
dc.contributor.author | Nived, O. | - |
dc.contributor.author | Fang, H. | - |
dc.contributor.author | Alarcon, G. S. | - |
dc.contributor.author | Gordon, C. | - |
dc.contributor.author | Merrill, J. T. | - |
dc.contributor.author | Fortin, P. R. | - |
dc.contributor.author | Bruce, I. N. | - |
dc.contributor.author | Isenberg, D. A. | - |
dc.contributor.author | Wallace, D. J. | - |
dc.contributor.author | Ramsey-Goldman, R. | - |
dc.contributor.author | Bae, S-C | - |
dc.contributor.author | Hanly, J. G. | - |
dc.contributor.author | Sanchez-Guerrero, J. | - |
dc.contributor.author | Clarke, A. E. | - |
dc.contributor.author | Aranow, C. B. | - |
dc.contributor.author | Manzi, S. | - |
dc.contributor.author | Urowitz, M. B. | - |
dc.contributor.author | Gladman, D. D. | - |
dc.contributor.author | Kalunian, K. C. | - |
dc.contributor.author | Costner, M. I. | - |
dc.contributor.author | Werth, V. P. | - |
dc.contributor.author | Zoma, A. | - |
dc.contributor.author | Bernatsky, S. | - |
dc.contributor.author | Ruiz-Irastorza, G. | - |
dc.contributor.author | Khamashta, M. A. | - |
dc.contributor.author | Jacobsen, S. | - |
dc.contributor.author | Buyon, J. P. | - |
dc.contributor.author | Maddison, P. | - |
dc.contributor.author | Dooley, M. A. | - |
dc.contributor.author | Van Vollenhoven, R. F. | - |
dc.contributor.author | Ginzler, E. | - |
dc.contributor.author | Stoll, T. | - |
dc.contributor.author | Peschken, C. | - |
dc.contributor.author | Jorizzo, J. L. | - |
dc.contributor.author | Callen, J. P. | - |
dc.contributor.author | Lim, S. S. | - |
dc.contributor.author | Fessler, B. J. | - |
dc.contributor.author | Inanc, M. | - |
dc.contributor.author | Kamen, D. L. | - |
dc.contributor.author | Rahman, A. | - |
dc.contributor.author | Steinsson, K. | - |
dc.contributor.author | Franks, A. G., Jr. | - |
dc.contributor.author | Sigler, L. | - |
dc.contributor.author | Hameed, S. | - |
dc.contributor.author | Pham, N. | - |
dc.contributor.author | Brey, R. | - |
dc.contributor.author | Weisman, M. H. | - |
dc.contributor.author | McGwin, G., Jr. | - |
dc.contributor.author | Magder, L. S. | - |
dc.contributor.author | Petri, M. | - |
dc.date.accessioned | 2021-08-02T18:27:06Z | - |
dc.date.available | 2021-08-02T18:27:06Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2015-01 | - |
dc.identifier.issn | 0961-2033 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/25661 | - |
dc.description.abstract | Objective Anti-C1q has been associated with systemic lupus erythematosus (SLE) and lupus nephritis in previous studies. We studied anti-C1q specificity for SLE (vs rheumatic disease controls) and the association with SLE manifestations in an international multicenter study. Methods Information and blood samples were obtained in a cross-sectional study from patients with SLE (n = 308) and other rheumatologic diseases (n = 389) from 25 clinical sites (84% female, 68% Caucasian, 17% African descent, 8% Asian, 7% other). IgG anti-C1q against the collagen-like region was measured by ELISA. Results Prevalence of anti-C1q was 28% (86/308) in patients with SLE and 13% (49/389) in controls (OR = 2.7, 95% CI: 1.8–4, p < 0.001). Anti-C1q was associated with proteinuria (OR = 3.0, 95% CI: 1.7–5.1, p < 0.001), red cell casts (OR = 2.6, 95% CI: 1.2–5.4, p = 0.015), anti-dsDNA (OR = 3.4, 95% CI: 1.9–6.1, p < 0.001) and anti-Smith (OR = 2.8, 95% CI: 1.5–5.0, p = 0.01). Anti-C1q was independently associated with renal involvement after adjustment for demographics, ANA, anti-dsDNA and low complement (OR = 2.3, 95% CI: 1.3–4.2, p < 0.01). Simultaneously positive anti-C1q, anti-dsDNA and low complement was strongly associated with renal involvement (OR = 14.9, 95% CI: 5.8–38.4, p < 0.01). Conclusions Anti-C1q was more common in patients with SLE and those of Asian race/ethnicity. We confirmed a significant association of anti-C1q with renal involvement, independent of demographics and other serologies. Anti-C1q in combination with anti-dsDNA and low complement was the strongest serological association with renal involvement. These data support the usefulness of anti-C1q in SLE, especially in lupus nephritis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.title | Anti-C1q antibodies in systemic lupus erythematosus | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bae, S-C | - |
dc.identifier.doi | 10.1177/0961203314547791 | - |
dc.identifier.scopusid | 2-s2.0-84918547572 | - |
dc.identifier.wosid | 000346177700006 | - |
dc.identifier.bibliographicCitation | LUPUS, v.24, no.1, pp.42 - 49 | - |
dc.relation.isPartOf | LUPUS | - |
dc.citation.title | LUPUS | - |
dc.citation.volume | 24 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 42 | - |
dc.citation.endPage | 49 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | RENAL-DISEASE ACTIVITY | - |
dc.subject.keywordPlus | COLLAGEN-LIKE REGION | - |
dc.subject.keywordPlus | PREDICTIVE-VALUE | - |
dc.subject.keywordPlus | IMMUNE DEPOSITS | - |
dc.subject.keywordPlus | C1Q DEFICIENCY | - |
dc.subject.keywordPlus | AUTOANTIBODIES | - |
dc.subject.keywordPlus | NEPHRITIS | - |
dc.subject.keywordPlus | COMPLEMENT | - |
dc.subject.keywordPlus | SERA | - |
dc.subject.keywordPlus | AUTOIMMUNITY | - |
dc.subject.keywordAuthor | Anti-dsDNA antibodies | - |
dc.subject.keywordAuthor | renal lupus | - |
dc.subject.keywordAuthor | systemic lupus erythematosus | - |
dc.identifier.url | https://journals.sagepub.com/doi/10.1177/0961203314547791 | - |
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