KRAS-driven ROS promote malignant transformation

Abstract

The mechanism underlying KRAS (Kirsten rat sarcoma viral oncogene homolog)-driven cellular transformation remains unclear because of the complexity of its downstream effectors. Park et al. recently reported that levels of reactive oxygen species (ROS) are increased by KRAS and are responsible for KRAS-driven malignant transformation, and further identified the signaling cascade involved as KRAS/p38/PDPK1/PKC delta/p47(phox)/NOX1. These findings provide new insight into the molecular mechanisms governing KRAS-driven malignant transformation.