Synthetic Lethal Screen of NAA20, a Catalytic Subunit Gene of NatB N-Terminal Acetylase in Saccharomyces cerevisiae
DC Field | Value | Language |
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dc.contributor.author | Lee, Kang-Eun | - |
dc.contributor.author | Ahn, Jun-Young | - |
dc.contributor.author | Kim, Jeong-Mok | - |
dc.contributor.author | Hwang, Cheol-Sang | - |
dc.date.accessioned | 2021-08-02T18:28:53Z | - |
dc.date.available | 2021-08-02T18:28:53Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2014-10 | - |
dc.identifier.issn | 1225-8873 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/25749 | - |
dc.description.abstract | The Saccharomyces cerevisiae NatB N-terminal acetylase contains a catalytic subunit Nan20 and an auxiliary subunit Naa25. To elucidate the cellular functions of the NatB, we utilized the Synthetic Genetic Array to screen for genes that are essential for cell growth in the absence of NAA20. The genome-wide synthetic lethal screen of NAA20 identified genes encoding for serine/threonine protein kinase Vps15, 1,3-beta-glucanosyltransferase Gas5, and a catabolic repression regulator Mig3. The present study suggests that the catalytic activity of the NatB N-terminal aceytase is involved in vacuolar protein sorting and cell wall maintenance. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MICROBIOLOGICAL SOCIETY KOREA | - |
dc.title | Synthetic Lethal Screen of NAA20, a Catalytic Subunit Gene of NatB N-Terminal Acetylase in Saccharomyces cerevisiae | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jeong-Mok | - |
dc.identifier.doi | 10.1007/s12275-014-3694-z | - |
dc.identifier.scopusid | 2-s2.0-84919948601 | - |
dc.identifier.wosid | 000342392100005 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MICROBIOLOGY, v.52, no.10, pp.842 - 848 | - |
dc.relation.isPartOf | JOURNAL OF MICROBIOLOGY | - |
dc.citation.title | JOURNAL OF MICROBIOLOGY | - |
dc.citation.volume | 52 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 842 | - |
dc.citation.endPage | 848 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.identifier.kciid | ART001915287 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | END RULE PATHWAY | - |
dc.subject.keywordPlus | CELLULAR-PROTEINS | - |
dc.subject.keywordPlus | GTPASE ARL3P | - |
dc.subject.keywordPlus | YEAST | - |
dc.subject.keywordPlus | ACETYLTRANSFERASE | - |
dc.subject.keywordPlus | REQUIRES | - |
dc.subject.keywordPlus | ACTIN | - |
dc.subject.keywordPlus | CYTOSKELETON | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordAuthor | N-terminal acetylation | - |
dc.subject.keywordAuthor | synthetic lethal screen | - |
dc.subject.keywordAuthor | NatB | - |
dc.subject.keywordAuthor | Naa20 | - |
dc.subject.keywordAuthor | synthetic genetic array | - |
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