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Doxycycline Enhances Survival and Self-Renewal of Human Pluripotent Stem Cells
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Chang, Mi-Yoon | - |
| dc.contributor.author | Rhee, Yong-Hee | - |
| dc.contributor.author | Yi, Sang-Hoon | - |
| dc.contributor.author | Lee, Su-Jae | - |
| dc.contributor.author | Kim, Rae-Kwon | - |
| dc.contributor.author | Kim, Hyongbum | - |
| dc.contributor.author | Park, Chang-Hwan | - |
| dc.contributor.author | Lee, Sang-Hun | - |
| dc.date.accessioned | 2021-08-02T18:30:14Z | - |
| dc.date.available | 2021-08-02T18:30:14Z | - |
| dc.date.issued | 2014-08 | - |
| dc.identifier.issn | 2213-6711 | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/25825 | - |
| dc.description.abstract | We here report that doxycycline, an antibacterial agent, exerts dramatic effects on human embryonic stem and induced pluripotent stem cells (hESC/iPSCs) survival and self-renewal. The survival-promoting effect was also manifest in cultures of neural stem cells (NSCs) derived from hESC/iPSCs. These doxycycline effects are not associated with its antibacterial action, but mediated by direct activation of a PI3K-AKT intracellular signal. These findings indicate doxycycline as a useful supplement for stem cell cultures, facilitating their growth and maintenance. | - |
| dc.format.extent | 12 | - |
| dc.language | 영어 | - |
| dc.language.iso | ENG | - |
| dc.publisher | Cell Press | - |
| dc.title | Doxycycline Enhances Survival and Self-Renewal of Human Pluripotent Stem Cells | - |
| dc.type | Article | - |
| dc.publisher.location | 미국 | - |
| dc.identifier.doi | 10.1016/j.stemcr.2014.06.013 | - |
| dc.identifier.scopusid | 2-s2.0-84924219709 | - |
| dc.identifier.wosid | 000340882400013 | - |
| dc.identifier.bibliographicCitation | Stem Cell Reports, v.3, no.2, pp 353 - 364 | - |
| dc.citation.title | Stem Cell Reports | - |
| dc.citation.volume | 3 | - |
| dc.citation.number | 2 | - |
| dc.citation.startPage | 353 | - |
| dc.citation.endPage | 364 | - |
| dc.type.docType | Article | - |
| dc.description.isOpenAccess | N | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Cell Biology | - |
| dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
| dc.relation.journalWebOfScienceCategory | Cell Biology | - |
| dc.subject.keywordPlus | DOPAMINE NEURONS | - |
| dc.subject.keywordPlus | IN-VITRO | - |
| dc.subject.keywordPlus | MICROGLIAL ACTIVATION | - |
| dc.subject.keywordPlus | NEURAL PRECURSORS | - |
| dc.subject.keywordPlus | HUMAN BLASTOCYSTS | - |
| dc.subject.keywordPlus | RAT MODEL | - |
| dc.subject.keywordPlus | DIFFERENTIATION | - |
| dc.subject.keywordPlus | MINOCYCLINE | - |
| dc.subject.keywordPlus | DERIVATION | - |
| dc.subject.keywordPlus | ISCHEMIA | - |
| dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S2213671114001994?via%3Dihub | - |
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