Knockdown of hepatoma-derived growth factor-related protein-3 induces apoptosis of H1299 cells via ROS-dependent and p53-independent NF-kappa B activation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yun, Hong Shik | - |
dc.contributor.author | Baek, Jeong-Hwa | - |
dc.contributor.author | Yim, Ji-Hye | - |
dc.contributor.author | Lee, Su-Jae | - |
dc.contributor.author | Lee, Chang-Woo | - |
dc.contributor.author | Song, Jie-Young | - |
dc.contributor.author | Um, Hong-Duck | - |
dc.contributor.author | Park, Jong Kuk | - |
dc.contributor.author | Park, In-Chul | - |
dc.contributor.author | Hwang, Sang-Gu | - |
dc.date.accessioned | 2021-08-02T18:30:33Z | - |
dc.date.available | 2021-08-02T18:30:33Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2014-07 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/25843 | - |
dc.description.abstract | We previously identified hepatoma-derived growth factor-related protein-3 (HRP-3) as a radioresistant biomarker in p53 wild-type A549 cells and found that p53-dependent induction of the PUMA pathway was a critical event in regulating the radioresistant phenotype. Here, we found that HRP-3 knockdown regulates the radioresistance of p53-null H1299 cells through a distinctly different molecular mechanism. HRP-3 depletion was sufficient to cause apoptosis of H1299 cells by generating substantial levels of reactive oxygen species (ROS) through inhibition of the Nrf2/HO-1 antioxidant pathway. Subsequent, ROS-dependent and p53-independent NF-kappa B activation stimulated expression of c-Myc and Noxa proteins, thereby inducing the apoptotic machinery. Our results thus extend the range of targets for the development of new drugs to treat both p53 wild-type or p53-null radioresistant lung cancer cells. (C) 2014 The Authors. Published by Elsevier Inc. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Knockdown of hepatoma-derived growth factor-related protein-3 induces apoptosis of H1299 cells via ROS-dependent and p53-independent NF-kappa B activation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Su-Jae | - |
dc.identifier.doi | 10.1016/j.bbrc.2014.05.039 | - |
dc.identifier.scopusid | 2-s2.0-84902869716 | - |
dc.identifier.wosid | 000343631400021 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.449, no.4, pp.471 - 476 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 449 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 471 | - |
dc.citation.endPage | 476 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | HDGF-RELATED PROTEIN-3 | - |
dc.subject.keywordPlus | C-MYC | - |
dc.subject.keywordPlus | DEPLETION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | MEMBER | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordAuthor | H1299 cells | - |
dc.subject.keywordAuthor | HRP-3 | - |
dc.subject.keywordAuthor | Myc/Noxa signaling | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | ROS | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.