Gene-environmental interaction between smoking and shared epitope on the development of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2021-08-02T18:30:55Z | - |
dc.date.available | 2021-08-02T18:30:55Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2014-06 | - |
dc.identifier.issn | 1756-1841 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/25865 | - |
dc.description.abstract | Objective The aim of this study was to determine the gene–environment interactions of smoking and shared epitope (SE) both separately and combined on anti-cyclic citrullinated peptide (CCP) antibodies in patients with rheumatoid arthritis (RA). Methods The literature was searched using the MEDLINE, EMBASE and Cochrane databases. A meta-analysis on the associations between tobacco exposure (TE) and/or SE and the development of anti-CCP antibodies in patients with RA was performed. Results Eight comparison studies with 5317 RA patients were considered in this meta-analysis. The odds ratio (OR) for positive anti-CCP antibodies in TE+/SE− patients with RA was increased compared with TE−/SE− patients (OR = 1.373, 95% CI = 1.111–1.698, P = 0.003). The ORs for positive anti-CCP antibodies in TE−/SE+ patients and TE+/SE+ patients with RA were also increased compared with TE−/SE− patients (OR = 2.678, 95% CI = 2.031–3.532, P < 1.0 × 10−9 in TE−/SE+; OR = 4.233, 95% CI = 2.458–7.291, P = 1.9 × 10−8 in TE+/SE+). Stratification by ethnicity indicated the same pattern as that shown in the overall group. The OR for positive anti-CCP antibodies in TE+/SE+ patients with RA was much higher than in TE−/SE− patients in Europeans and Asians (OR = 3.879, 95% CI = 2.203–6.830, P = 2.6 × 10−7; OR = 10.504, 95% CI = 3.182–34.67, P = 1.1 × 10−4). Conclusions This meta-analysis suggests a gene–environmental interaction between smoking and SE for the development of anti-CCP antibodies. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Gene-environmental interaction between smoking and shared epitope on the development of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bae, Sang-Cheol | - |
dc.identifier.doi | 10.1111/1756-185X.12307 | - |
dc.identifier.scopusid | 2-s2.0-84904325776 | - |
dc.identifier.wosid | 000340668200007 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, v.17, no.5, pp.528 - 535 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES | - |
dc.citation.title | INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES | - |
dc.citation.volume | 17 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 528 | - |
dc.citation.endPage | 535 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | CIGARETTE-SMOKING | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | AUTOANTIBODIES | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | AUTOIMMUNITY | - |
dc.subject.keywordPlus | NATIONWIDE | - |
dc.subject.keywordPlus | INCREASES | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordAuthor | anti-CCP antibodies | - |
dc.subject.keywordAuthor | rheumatoid arthritis | - |
dc.subject.keywordAuthor | shared epitope | - |
dc.subject.keywordAuthor | smoking | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/1756-185X.12307 | - |
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