Silicon Tetrapyrazinoporphyrazine Derivatives-Incorporated Carbohydrate-Based Block Copolymer Micelles for Photodynamic Therapy
DC Field | Value | Language |
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dc.contributor.author | Park, Jong Min | - |
dc.contributor.author | Jung, Chang Young | - |
dc.contributor.author | Jang, Woo-Dong | - |
dc.contributor.author | Jaung, Jae Yun | - |
dc.date.accessioned | 2021-07-30T05:00:35Z | - |
dc.date.available | 2021-07-30T05:00:35Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 2576-6422 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/2592 | - |
dc.description.abstract | Developing nonaggregated photosensitizers (PSs) for efficient photodynamic therapy (PDT) using polymeric micelles (PMs) has been challenging. In this study, axially substituted nonaggregated silicon tetrapyrazinoporphyrazine (SiTPyzPz) derivatives in carbohydrate-based block glycopolymer-based PMs were designed and used as PSs for PDT. To achieve the nonaggregated PSs, SiTPyzPz was axially substituted with trihexylsiloxy (THS) groups to form SiTPyzPz-THS, which exhibited highly monomeric behaviors in organic solvents. Moreover, three block copolymers were prepared via reversible addition-fragmentation chain transfer (RAFT) polymerization. Each copolymer comprised hydrophobic polystyrene blocks and loadable SiTPyzPz-THS, and one or two consisted of two possible hydrophilic blocks, polyethylene glycol or poly(glucosylethyl methacrylate). The self-assembly of SiTPyzPz-THS and the block copolymers in aqueous solvents induced the formation of spherical PMs with core-shell or core-shell-corona structures. The SiTPyzPz-THS in the PMs exhibited monomeric state, intense fluorescence emission, and outstanding singlet oxygen generation; moreover, it did not form aggregates. During the in vitro test, which was performed to investigate the PDT efficiency, the PMs, which consisted of poly(glucosylethyl methacrylate) shells, exhibited high photocytotoxicity and cellular internalization ability. Consequently, the PM systems of nonaggregated PSs and carbohydrate-based block copolymers could become very promising materials for PDT owing to their photophysicochemical properties and considerable selectivity against cancer cells. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Silicon Tetrapyrazinoporphyrazine Derivatives-Incorporated Carbohydrate-Based Block Copolymer Micelles for Photodynamic Therapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jaung, Jae Yun | - |
dc.identifier.doi | 10.1021/acsabm.0c00256 | - |
dc.identifier.scopusid | 2-s2.0-85086837653 | - |
dc.identifier.wosid | 000630168200001 | - |
dc.identifier.bibliographicCitation | ACS APPLIED BIO MATERIALS, v.4, no.3, pp.1988 - 2000 | - |
dc.relation.isPartOf | ACS APPLIED BIO MATERIALS | - |
dc.citation.title | ACS APPLIED BIO MATERIALS | - |
dc.citation.volume | 4 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1988 | - |
dc.citation.endPage | 2000 | - |
dc.type.rims | ART | - |
dc.type.docType | Article in Press | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | SELF-ASSEMBLED MICELLES | - |
dc.subject.keywordPlus | PHOTOPHYSICAL PROPERTIES | - |
dc.subject.keywordPlus | PHTHALOCYANINE PHOTOSENSITIZERS | - |
dc.subject.keywordPlus | POLYMERIC MICELLES | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | FLUORESCENCE | - |
dc.subject.keywordPlus | COMBINATION | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | AGENT | - |
dc.subject.keywordAuthor | photodynamic therapy | - |
dc.subject.keywordAuthor | silicon tetrapyrazinoporphyrazine | - |
dc.subject.keywordAuthor | carbohydrate-based block copolymers | - |
dc.subject.keywordAuthor | self-assembly | - |
dc.subject.keywordAuthor | polymeric micelles | - |
dc.identifier.url | https://pubs.acs.org/doi/10.1021/acsabm.0c00256 | - |
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