Low-dose gamma-radiation inhibits IL-1 beta-induced dedifferentiation and inflammation of articular chondrocytes via blockage of catenin signaling
DC Field | Value | Language |
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dc.contributor.author | Hong, Eun-Hee | - |
dc.contributor.author | Song, Jie-Young | - |
dc.contributor.author | Lee, Su-Jae | - |
dc.contributor.author | Park, In-Chul | - |
dc.contributor.author | Um, Hong-Duck | - |
dc.contributor.author | Park, Jong Kuk | - |
dc.contributor.author | Lee, Kee-Ho | - |
dc.contributor.author | Nam, Seon Young | - |
dc.contributor.author | Hwang, Sang-Gu | - |
dc.date.accessioned | 2021-08-02T18:52:18Z | - |
dc.date.available | 2021-08-02T18:52:18Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2014-02 | - |
dc.identifier.issn | 1521-6543 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/26548 | - |
dc.description.abstract | Although low-dose radiation (LDR) regulates a wide range of biological processes, limited information is available on the effects of LDR on the chondrocyte phenotype. Here, we found that LDR, at doses of 0.5-2 centiGray (cGy), inhibited interleukin (IL)-1 beta-induced chondrocyte destruction without causing side effects, such as cell death and senescence. IL-1 beta treatment induced an increase in the expression of alpha-, beta-, and gamma-catenin proteins in chondrocytes via Akt signaling, thereby promoting dedifferentiation through catenin-dependent suppression of Sox-9 transcription factor expression and induction of inflammation through activation of the NF-kappa B pathway. Notably, LDR blocked cartilage disorders by inhibiting IL-1 beta-induced catenin signaling and subsequent catenin-dependent suppression of the Sox-9 pathway and activation of the NF-kappa B pathway, without directly altering catenin expression. LDR also inhibited chondrocyte destruction through the catenin pathway induced by epidermal growth factor, phorbol 12-myristate 13-acetate, and retinoic acid. Collectively, these results identify the molecular mechanisms by which LDR suppresses pathophysiological processes and establish LDR as a potentially valuable therapeutic tool for patients with cytokine- or soluble factors-mediated cartilage disorders. (c) 2014 The Authors IUBMB Life published by Wiley Periodicals, Inc. on behalf of International Union of Biochemistry and Molecular Biology, 66(2):128-137, 2014 | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | Low-dose gamma-radiation inhibits IL-1 beta-induced dedifferentiation and inflammation of articular chondrocytes via blockage of catenin signaling | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Su-Jae | - |
dc.identifier.doi | 10.1002/iub.1248 | - |
dc.identifier.scopusid | 2-s2.0-84896392147 | - |
dc.identifier.wosid | 000332781600008 | - |
dc.identifier.bibliographicCitation | IUBMB LIFE, v.66, no.2, pp.128 - 137 | - |
dc.relation.isPartOf | IUBMB LIFE | - |
dc.citation.title | IUBMB LIFE | - |
dc.citation.volume | 66 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 128 | - |
dc.citation.endPage | 137 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | ALPHA-CATENIN | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | IRRADIATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | FREQUENCY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | catenin | - |
dc.subject.keywordAuthor | dedifferentiation | - |
dc.subject.keywordAuthor | low dose radiation | - |
dc.subject.keywordAuthor | chondrocytes | - |
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