Non-Lymphoma Hematological Malignancies in Systemic Lupus Erythematosusopen access
- Authors
- Lu, Mary; Bernatsky, Sasha; Ramsey-Goldman, Rosalind; Petri, Michelle; Manzi, Susan; Urowitz, Murray B.; Gladman, Dafna; Fortin, Paul R.; Ginzler, Ellen M.; Yelin, Edward; Bae, Sang-Cheol; Wallace, Daniel J.; Jacobsen, Soren; Dooley, Mary Anne; Peschken, Christine A.; Alarcon, Graciela S.; Nived, Ola; Gottesman, Lena; Criswell, Lindsey A.; Sturfelt, Gunnar; Dreyer, Lene; Lee, Jennifer L.; Clarke, Ann E.
- Issue Date
- Oct-2013
- Publisher
- KARGER
- Keywords
- Systemic lupus erythematosus; Malignancy; Cancer
- Citation
- ONCOLOGY, v.85, no.4, pp.235 - 240
- Indexed
- SCIE
SCOPUS
- Journal Title
- ONCOLOGY
- Volume
- 85
- Number
- 4
- Start Page
- 235
- End Page
- 240
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/26626
- DOI
- 10.1159/000350165
- ISSN
- 0030-2414
- Abstract
- Objective: To describe non-lymphoma hematological malignancies in systemic lupus erythematosus (SLE). Methods: A large SLE cohort was linked to cancer registries. We examined the types of non-lymphoma hematological cancers. Results: In 16,409 patients, 115 hematological cancers [including myelodysplastic syndrome (MDS)] occurred. Among these, 33 were non-lymphoma. Of the 33 non-lymphoma cases, 13 were of lymphoid lineage: multiple myeloma (n = 5), plasmacytoma (n = 3), B cell chronic lymphocytic leukemia (B-CLL; n = 3), precursor cell lymphoblastic leukemia (n = 1) and unspecified lymphoid leukemia (n = 1). The remaining 20 cases were of myeloid lineage: MDS (n = 7), acute myeloid leukemia (AML; n = 7), chronic myeloid leukemia (CML; n = 2) and 4 unspecified leukemias. Most of these malignancies occurred in female Caucasians, except for plasma cell neoplasms (4/5 multiple myeloma and 1/3 plasmacytoma cases occurred in blacks). Conclusions: In this large SLE cohort, the most common non-lymphoma hematological malignancies were myeloid types (MDS and AML). This is in contrast to the general population, where lymphoid types are 1.7 times more common than myeloid non-lymphoma hematological malignancies. Most (80%) multiple myeloma cases occurred in blacks; this requires further investigation. (C) 2013 S. Karger AG, Basel
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