Fractionated radiation-induced nitric oxide promotes expansion of glioma stem-like cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Rae-Kwon | - |
dc.contributor.author | Suh, Yongjoon | - |
dc.contributor.author | Cui, Yan-Hong | - |
dc.contributor.author | Hwang, Eunji | - |
dc.contributor.author | Lim, Eun-Jung | - |
dc.contributor.author | Yoo, Ki-Chun | - |
dc.contributor.author | Lee, Ga-Haeng | - |
dc.contributor.author | Yi, Joo-Mi | - |
dc.contributor.author | Kang, Seok-Gu | - |
dc.contributor.author | Lee, Su-Jae | - |
dc.date.accessioned | 2021-08-02T18:54:54Z | - |
dc.date.available | 2021-08-02T18:54:54Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2013-09 | - |
dc.identifier.issn | 1347-9032 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/26659 | - |
dc.description.abstract | Glioblastoma remains an incurable brain disease due to the prevalence of its recurrence. Considerable evidence suggests that glioma stem-like cells are responsible for glioma relapse after treatment, which commonly involves ionizing radiation. Here, we found that fractionated ionizing radiation (2Gy/day for 3days) induced glioma stem-like cell expansion and resistance to anticancer treatment such as cisplatin (50M) or taxol (500nM), or by ionizing radiation (10Gy) in both glioma cell lines (U87, U373) and patient-derived glioma cells. Of note, concomitant increase of nitric oxide production occurred with the radiation-induced increase of the glioma stem-like cell population through upregulation of inducible nitric oxide synthase (iNOS). In line with this observation, downregulation of iNOS effectively reduced the glioma stem-like cell population and decreased resistance to anticancer treatment. Collectively, our results suggest that targeting iNOS in combination with ionizing radiation might increase the efficacy of radiotherapy for glioma treatment. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Fractionated radiation-induced nitric oxide promotes expansion of glioma stem-like cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Su-Jae | - |
dc.identifier.doi | 10.1111/cas.12207 | - |
dc.identifier.scopusid | 2-s2.0-84883459098 | - |
dc.identifier.wosid | 000325680800005 | - |
dc.identifier.bibliographicCitation | CANCER SCIENCE, v.104, no.9, pp.1172 - 1177 | - |
dc.relation.isPartOf | CANCER SCIENCE | - |
dc.citation.title | CANCER SCIENCE | - |
dc.citation.volume | 104 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1172 | - |
dc.citation.endPage | 1177 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | BRAIN-TUMORS | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | GROWTH | - |
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