Interaction of HLA-DRB1*09:01 and*04:05 with Smoking Suggests Distinctive Mechanisms of Rheumatoid Arthritis Susceptibility Beyond the Shared Epitope
DC Field | Value | Language |
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dc.contributor.author | Bang, So-Young | - |
dc.contributor.author | Lee, Hye-Soon | - |
dc.contributor.author | Lee, Kyung Wha | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.date.accessioned | 2021-08-02T18:55:54Z | - |
dc.date.available | 2021-08-02T18:55:54Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2013-07 | - |
dc.identifier.issn | 0315-162X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/26694 | - |
dc.description.abstract | Objective. Although HLA-DRB1 shared epitope (SE) alleles and HLA-DRB1*09:01 have repeatedly been shown to be associated with susceptibility to rheumatoid arthritis (RA), the effect of each allele on levels of anticyclic citrullinated peptide autoantibodies (anti-CCP) and interaction with cigarette smoking in RA remains to be fully defined. We investigated whether HLA-DRB1 risk alleles influence anti-CCP levels and whether each allele interacts with smoking in anti-CCP-positive or -negative RA. Methods. All patients with RA (n = 1924) and controls (n = 1119) were Korean. The HLA-DRB1 4-digit genotyping was performed by standard PCR-sequencing based typing method. OR and biologic interactions as departures from additivity or multiplicity were analyzed by logistic regression. Results. SE alleles were significantly associated with increased anti-CCP levels. Conversely, HLA-DRB1*09:01 was associated with reduced levels, in both SE-positive and SE-negative patients. Each of SE alleles interacted significantly with smoking, whereas HLA-DRB1*09:01 did not. Interactions between the 2 most significant risk alleles, HLA-DRB1*04:05 and HLA-DRB1*09:01, (attributable proportion = 0.68, 95% CI 0.46-0.89, multiplicity p = 0.012) significantly increased RA susceptibility regardless of anti-CCP and smoking status. Smoking increased the risk for RA by significant interaction with the heterozygote HLA-DRB1*04:05/*09:01. Conclusion. HLA-DRB1*09:01 differs from SE alleles with regard to anti-CCP levels and interaction with smoking, suggesting a distinct mechanism of HLA-DRB1*09:01 in the pathogenesis of RA that may bypass anti-CCP formation. Also, a significant increase of the HLA-DRB1*04:05/*09:01 heterozygote in RA susceptibility may be attributable to the synergistic contribution of 2 different pathways in which 2 alleles participate independently. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | J RHEUMATOL PUBL CO | - |
dc.title | Interaction of HLA-DRB1*09:01 and*04:05 with Smoking Suggests Distinctive Mechanisms of Rheumatoid Arthritis Susceptibility Beyond the Shared Epitope | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bang, So-Young | - |
dc.contributor.affiliatedAuthor | Lee, Hye-Soon | - |
dc.contributor.affiliatedAuthor | Bae, Sang-Cheol | - |
dc.identifier.doi | 10.3899/jrheum.121280 | - |
dc.identifier.scopusid | 2-s2.0-84879964739 | - |
dc.identifier.wosid | 000321993800006 | - |
dc.identifier.bibliographicCitation | JOURNAL OF RHEUMATOLOGY, v.40, no.7, pp.1054 - 1062 | - |
dc.relation.isPartOf | JOURNAL OF RHEUMATOLOGY | - |
dc.citation.title | JOURNAL OF RHEUMATOLOGY | - |
dc.citation.volume | 40 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1054 | - |
dc.citation.endPage | 1062 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | CYCLIC CITRULLINATED PEPTIDE | - |
dc.subject.keywordPlus | GENE-ENVIRONMENT INTERACTION | - |
dc.subject.keywordPlus | HLA-DRB1 ALLELES | - |
dc.subject.keywordPlus | RISK-FACTOR | - |
dc.subject.keywordPlus | ANTIBODY | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | AUTOANTIBODIES | - |
dc.subject.keywordPlus | AUTOIMMUNITY | - |
dc.subject.keywordPlus | REGARDLESS | - |
dc.subject.keywordAuthor | RHEUMATOID ARTHRITIS | - |
dc.subject.keywordAuthor | HLA-DRB1*09:01 | - |
dc.subject.keywordAuthor | SHARED EPITOPE | - |
dc.subject.keywordAuthor | ANTICITRULLINATED PROTEIN AUTOANTIBODIES | - |
dc.subject.keywordAuthor | SMOKING | - |
dc.identifier.url | https://www.jrheum.org/content/40/7/1054 | - |
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