Lack of association between Poly(ADP-ribose) polymerase (PARP) polymorphisms and rheumatoid arthritis in a Korean population
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Kyeong-A | - |
dc.contributor.author | Bang, So-Young | - |
dc.contributor.author | Park, Byung Lae | - |
dc.contributor.author | Kim, Jeong-Hyun | - |
dc.contributor.author | Shin, Hyoung Doo | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.date.accessioned | 2021-08-02T19:31:00Z | - |
dc.date.available | 2021-08-02T19:31:00Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2012-01 | - |
dc.identifier.issn | 0172-8172 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/27626 | - |
dc.description.abstract | Several studies have investigated the roles of genetic polymorphisms in rheumatoid arthritis (RA). Some of these studies reported that polymorphisms of poly(ADP-ribose) polymerase 1 gene (PARP-1) are linked to rheumatoid arthritis. Poly(ADP-ribose) polymerase is an enzyme involved in DNA repair, genomic stability, apoptosis, gene transcription, proliferation, and autoimmunity. To determine whether genetic polymorphisms of PARP-1 are related to rheumatoid arthritis in a Korean population, six single nucleotide polymorphisms (SNPs), which were selected based on LDs and minor allele frequency (MAF > 0.05) in our previous study, were genotyped in 1,202 patients with rheumatoid arthritis and 979 unrelated healthy controls. As a result, no significant association between the susceptibility to rheumatoid arthritis and PAPR-1 polymorphisms was found. However, in further analysis depending on the radiological severity of rheumatoid arthritis, one PARP-1 polymorphism, rs1805413 (OR = 0.11; 95% CI = 0.02-0.55; P = 0.007; P (corr) = 0.04), and one haplotype (ht6, OR = 0.11; 95% CI = 0.02-0.55; P = 0.007; P (corr) = 0.04) were significantly associated with the radiological severity risk of RA in a recessive model. In addition, a recessive model revealed a correlation between one RA haplotype (ht4) and anti-CCP antibody negativity (OR 0.24, 95% CI 0.10-0.63, P = 0.003; P (corr) = 0.02). Despite a possible association between PARP-1 and the radiological severity of RA, this study found no statistical association between PARP-1 polymorphisms and the susceptibility to rheumatoid arthritis in a Korean population. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.title | Lack of association between Poly(ADP-ribose) polymerase (PARP) polymorphisms and rheumatoid arthritis in a Korean population | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bang, So-Young | - |
dc.contributor.affiliatedAuthor | Bae, Sang-Cheol | - |
dc.identifier.doi | 10.1007/s00296-010-1589-9 | - |
dc.identifier.scopusid | 2-s2.0-84857117095 | - |
dc.identifier.wosid | 000299007300015 | - |
dc.identifier.bibliographicCitation | RHEUMATOLOGY INTERNATIONAL, v.32, no.1, pp.91 - 96 | - |
dc.relation.isPartOf | RHEUMATOLOGY INTERNATIONAL | - |
dc.citation.title | RHEUMATOLOGY INTERNATIONAL | - |
dc.citation.volume | 32 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 91 | - |
dc.citation.endPage | 96 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | VAL762ALA POLYMORPHISM | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | HAPLOTYPE | - |
dc.subject.keywordPlus | PADI4 | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | GENOMEWIDE | - |
dc.subject.keywordPlus | ALLELES | - |
dc.subject.keywordAuthor | Rheumatoid arthritis (RA) | - |
dc.subject.keywordAuthor | Poly(ADP-ribose) polymerase (PARP) | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Susceptibility | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00296-010-1589-9 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.