Bioreducible polymer-conjugated oncolytic adenovirus for hepatoma-specific therapy via systemic administration
DC Field | Value | Language |
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dc.contributor.author | Kim, Pyung-Hwan | - |
dc.contributor.author | Kim, Jaesung | - |
dc.contributor.author | Kim, Tae-il | - |
dc.contributor.author | Nam, Hye Yeong | - |
dc.contributor.author | Yockman, James W. | - |
dc.contributor.author | Kim, Minjung | - |
dc.contributor.author | Kim, Sung Wan | - |
dc.contributor.author | Yun, Chae-Ok | - |
dc.date.accessioned | 2021-08-02T19:31:25Z | - |
dc.date.available | 2021-08-02T19:31:25Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2011-12 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/27646 | - |
dc.description.abstract | Systemic administration of adenovirus (Ad) vectors is complicated by host immune responses and viral accumulation in the liver, resulting in a short circulatory virus half-life, low efficacy, and host side effects. Ad surface modification is thus required to enhance safety and therapeutic efficacy. An arginine-grafted bioreducible polymer (ABP) was chemically conjugated to the Ad surface, generating Ad-Delta E1/GFP-ABP. A hepatocellular carcinoma [HCC]-selective oncolytic Ad complex, YKL-1001-ABP, was also generated. Transduction efficiency of Ad-Delta E1/GFP-ABP was enhanced compared to naked Ad-Delta E1/GFP. YKL-1001-ABP elicited an enhanced and specific killing effect in liver cancer cells (Huh7 and HepG2) expressing alpha-fetoprotein (AFP). Compared with naked Ad, systemic administration of ABP-conjugated Ad resulted in reduced liver toxicity and interleukin (IL)-6 production in vitro and in vivo. Ad-Delta E1/GFP-ABP was more resistant to the neutralizing effects of human serum compared to naked Ad-Delta E1/GFP. ABP conjugation extended blood circulation time 45-fold and reduced anti-Ad Ab neutralization. Moreover, systemic administration of YKL-1001-ABP markedly suppressed growth of Huh7 hepatocellular carcinoma. These results demonstrate that chemical conjugation of ABP to the Ad surface improves safety and efficacy, indicating that ABP-conjugated Ad is a potentially useful cancer therapeutic agent to target cancer via systemic administration. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | Bioreducible polymer-conjugated oncolytic adenovirus for hepatoma-specific therapy via systemic administration | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yun, Chae-Ok | - |
dc.identifier.doi | 10.1016/j.biomaterials.2011.08.066 | - |
dc.identifier.scopusid | 2-s2.0-80053615339 | - |
dc.identifier.wosid | 000296684200019 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.32, no.35, pp.9328 - 9342 | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 32 | - |
dc.citation.number | 35 | - |
dc.citation.startPage | 9328 | - |
dc.citation.endPage | 9342 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | CANCER GENE-THERAPY | - |
dc.subject.keywordPlus | INNATE IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | POLYETHYLENE-GLYCOL | - |
dc.subject.keywordPlus | DELIVERY-SYSTEMS | - |
dc.subject.keywordPlus | NEUTRALIZING ANTIBODY | - |
dc.subject.keywordPlus | VECTORS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | VITRO | - |
dc.subject.keywordPlus | EFFICIENCY | - |
dc.subject.keywordAuthor | Oncolytic adenovirus | - |
dc.subject.keywordAuthor | Arginine-grafted bioreducible polymer | - |
dc.subject.keywordAuthor | Chemical conjugation | - |
dc.subject.keywordAuthor | Cationic polymer | - |
dc.subject.keywordAuthor | Systemic delivery of Ad | - |
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