Source imaging of P300 auditory evoked potentials and clinical correlations in patients with posttraumatic stress disorder
DC Field | Value | Language |
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dc.contributor.author | Bae, Kyung-Yeol | - |
dc.contributor.author | Kim, Do-Won | - |
dc.contributor.author | Im, Chang-Hwan | - |
dc.contributor.author | Lee, Seung-Hwan | - |
dc.date.accessioned | 2021-08-02T19:31:26Z | - |
dc.date.available | 2021-08-02T19:31:26Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2011-12 | - |
dc.identifier.issn | 0278-5846 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/27647 | - |
dc.description.abstract | Objective: Posttraumatic stress disorder (PTSD) is associated with abnormal information processing. The P300 component of event-related potentials (ERPs) is known to be a useful marker of information processing. The purposes of this study were to determine the P300 current source density in PTSD patients, and its relationship with symptom severity. Methods: ERPs were recorded in 30 PTSD patients and 33 healthy controls while participants were performing the auditory oddball task. We compared P300 current source density data - obtained by standardized low-resolution brain electromagnetic tomography (sLORETA) - between the two groups. The correlation between P300 current source density and clinical symptoms (as evaluated using the Korean version of the Structured Interview for PTSD K-SIPS and Davidson Trauma Scale - K-DTS) was conducted. Results: In PTSD patients, the current source density of P300 is significantly reduced in the inferior frontal gyrus, precentral gyrus, insula, and anterior cingulate compared to healthy controls. Total K-DTS scores were correlated with the P300 current source density in the posterior cingulate gyrus. The K-SIP B items (re-experiencing) and K-SIB D items (increased arousal) were positively correlated with P300 current source densities in several brain regions located in the frontal, parietal, and temporal lobe (p<0.05). Conversely, the K-SIP C items (avoidance and numbing) were negatively correlated with P300 current source densities in the superior and middle frontal gyri in the frontal lobes (p<0.05). Conclusion: The P300 current source densities reflected the pathophysiology of PTSD patients. PTSD symptoms were related to different neural activities, depending on their symptom characteristics. (C) 2011 Elsevier Inc All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Source imaging of P300 auditory evoked potentials and clinical correlations in patients with posttraumatic stress disorder | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Im, Chang-Hwan | - |
dc.identifier.doi | 10.1016/j.pnpbp.2011.08.002 | - |
dc.identifier.scopusid | 2-s2.0-82455192391 | - |
dc.identifier.wosid | 000297831900017 | - |
dc.identifier.bibliographicCitation | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v.35, no.8, pp.1908 - 1917 | - |
dc.relation.isPartOf | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | - |
dc.citation.title | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | - |
dc.citation.volume | 35 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1908 | - |
dc.citation.endPage | 1917 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | MEDIAL PREFRONTAL CORTEX | - |
dc.subject.keywordPlus | CHILDHOOD SEXUAL-ABUSE | - |
dc.subject.keywordPlus | SCRIPT-DRIVEN IMAGERY | - |
dc.subject.keywordPlus | CEREBRAL-BLOOD-FLOW | - |
dc.subject.keywordPlus | FUNCTIONAL NEUROANATOMY | - |
dc.subject.keywordPlus | MENTAL-DISORDERS | - |
dc.subject.keywordPlus | WORKING-MEMORY | - |
dc.subject.keywordPlus | DISSOCIATIVE RESPONSES | - |
dc.subject.keywordPlus | NEURAL CIRCUITRY | - |
dc.subject.keywordPlus | BRAIN ACTIVATION | - |
dc.subject.keywordAuthor | Current source density | - |
dc.subject.keywordAuthor | P300 | - |
dc.subject.keywordAuthor | Posttraumatic stress disorder | - |
dc.subject.keywordAuthor | sLORETA | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0278584611002491?via%3Dihub | - |
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