Eckol suppresses maintenance of sternness and malignancies in glioma stem-like cells
DC Field | Value | Language |
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dc.contributor.author | Hyun, Kyung-Hwan | - |
dc.contributor.author | Yoon, Chang-Hwan | - |
dc.contributor.author | Kim, Rae-Kwon | - |
dc.contributor.author | Lim, Eun-Jung | - |
dc.contributor.author | An, Sungkwan | - |
dc.contributor.author | Park, Myung-Jin | - |
dc.contributor.author | Hyun, Jin-Won | - |
dc.contributor.author | Suh, Yongjoon | - |
dc.contributor.author | Kim, Min-Jung | - |
dc.contributor.author | Lee, Su-Jae | - |
dc.date.accessioned | 2021-08-02T19:51:28Z | - |
dc.date.available | 2021-08-02T19:51:28Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2011-07 | - |
dc.identifier.issn | 0041-008X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/28112 | - |
dc.description.abstract | A subpopulation of cancer cells with stem cell properties is responsible for tumor maintenance and progression, and may contribute to resistance to anticancer treatments. Thus, compounds that target cancer stem-like cells could be usefully applied to destroy cancer. In this study, we investigated the effect of Eckol, a phlorotannin compound, on sternness and malignancies in glioma stem-like cells. To determine whether Eckol targets glioma stem-like cells, we examined whether Eckol treatment could change the expression levels of glioma stem-like cell markers and self-renewal-related proteins as well as the sphere forming ability, and the sensitivity to anticancer treatments. Alterations in the malignant properties of sphere-derived cells by Eckol were also investigated by soft-agar colony forming assay, by xenograft assay in nude mice, and by cell invasion assay. Treatment of sphere-forming glioma cells with Eckol effectively decreased the sphere formation as well as the CD133(+) cell population. Eckol treatment suppressed expression of the glioma stem-like cell markers and the self-renewal-related proteins without cell death. Moreover, treatment of glioma stem-like cells with Eckol significantly attenuated anchorage-independent growth on soft agar and tumor formation in xenograft mice. Importantly, Eckol treatment effectively reduced the resistance of glioma stem-like cells to ionizing radiation and temozolomide. Treatment of glioma stem-like cells with Eckol markedly blocked both phosphoinositide 3-kinase-Akt and Ras-Raf-1-Erk signaling pathways. These results indicate that the natural phlorotannin Eckol suppresses sternness and malignancies in glioma stem-like cells, and thereby makes glioma stem-like cells more sensitive to anticancer treatments, providing novel therapeutic strategies targeting specifically cancer stem-like cells. (C) 2011 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Eckol suppresses maintenance of sternness and malignancies in glioma stem-like cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Su-Jae | - |
dc.identifier.doi | 10.1016/j.taap.2011.04.006 | - |
dc.identifier.scopusid | 2-s2.0-79958004725 | - |
dc.identifier.wosid | 000291777300004 | - |
dc.identifier.bibliographicCitation | TOXICOLOGY AND APPLIED PHARMACOLOGY, v.254, no.1, pp.32 - 40 | - |
dc.relation.isPartOf | TOXICOLOGY AND APPLIED PHARMACOLOGY | - |
dc.citation.title | TOXICOLOGY AND APPLIED PHARMACOLOGY | - |
dc.citation.volume | 254 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 32 | - |
dc.citation.endPage | 40 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | RADIATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordAuthor | Eckol | - |
dc.subject.keywordAuthor | Glioma stem-like cells | - |
dc.subject.keywordAuthor | Self-renewal | - |
dc.subject.keywordAuthor | Malignant phenotype | - |
dc.subject.keywordAuthor | Resistance to anticancer treatments | - |
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