Risk and Characteristics of Postcolonoscopy Interval Colorectal Cancer after a Positive Fecal Test: A Nationwide Population-Based Study in Korea
DC Field | Value | Language |
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dc.contributor.author | Lee, Chang Kyun | - |
dc.contributor.author | Choi, Kui Son | - |
dc.contributor.author | Eun, Chang Soo | - |
dc.contributor.author | Park, Dong-Il | - |
dc.contributor.author | Han, Dong Soo | - |
dc.contributor.author | Yoon, Minjoo | - |
dc.contributor.author | Suh, Mina | - |
dc.contributor.author | Jun, Jae Kwan | - |
dc.date.accessioned | 2021-07-30T05:07:27Z | - |
dc.date.available | 2021-07-30T05:07:27Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2018-01 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3176 | - |
dc.description.abstract | Purpose Fecal tests remain a mainstay of population-based colorectal cancer (CRC) screening programs worldwide. However, data on interval CRC (iCRC) arising after follow-up colonoscopy of a positive fecal test are scarce. We conducted a nationwide population-based study to reveal the risk and characteristics of iCRC in this setting. Materials and Methods We searched the National Cancer Screening Program for CRC database in Korea (2005-2010). Incidence of iCRC within the program was estimated, then Cox proportional-hazards regression analysis was performed to determine the independent predictors of iCRC. The clinical characteristics of iCRC were compared with screen-detected CRC (sCRC). Results We identified 280 iCRC among 150,660 negative colonoscopies as a follow-up exam to a positive fecal immunochemical test (FIT), and 2,427 sCRC. The overall incidence of iCRC was 0.49/1,000 person-years (95% confidence interval [CI], 0.48 to 0.51). iCRC was more likely to occur in men (adjusted hazard ratio [aHR], 1.79; 95% CI, 1.39 to 2.30) and elderly patients (aHR, 1.77; 95% CI, 1.38 to 2.28 in 65-74 years; aHR, 3.13, 95% CI, 2.13 to 4.60 in ≥ 75 years). The National Quality Improvement Program for colonoscopy reduced a short-term risk of iCRC (aHR, 0.48; 95% CI, 0.27 to 0.87). Compared with sCRC, iCRC was more likely to occur in the proximal colon, be diagnosed at the localized stage, and have a lower CRC mortality (32.7 vs. 17.4%, 56.8 vs. 34.1%, and 12.5 vs. 17.7%, respectively; all p < 0.05). Conclusion In a population-based CRC screening program with FIT, the burden of iCRC after follow-up colonoscopy was substantial. Men and elderly patients possess a significantly higher risk of iCRC. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN CANCER ASSOCIATION | - |
dc.title | Risk and Characteristics of Postcolonoscopy Interval Colorectal Cancer after a Positive Fecal Test: A Nationwide Population-Based Study in Korea | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Eun, Chang Soo | - |
dc.contributor.affiliatedAuthor | Han, Dong Soo | - |
dc.identifier.doi | 10.4143/crt.2017.027 | - |
dc.identifier.scopusid | 2-s2.0-85040463145 | - |
dc.identifier.wosid | 000422912900006 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, v.50, no.1, pp.50 - 59 | - |
dc.relation.isPartOf | CANCER RESEARCH AND TREATMENT | - |
dc.citation.title | CANCER RESEARCH AND TREATMENT | - |
dc.citation.volume | 50 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 50 | - |
dc.citation.endPage | 59 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002308072 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | SCREENING-PROGRAM | - |
dc.subject.keywordPlus | COLONOSCOPY | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | PREDICTORS | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | ENDOSCOPY | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | NEOPLASMS | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | RATES | - |
dc.subject.keywordAuthor | Colonoscopy | - |
dc.subject.keywordAuthor | Colorectal neoplasms | - |
dc.subject.keywordAuthor | Early detection of cancer | - |
dc.identifier.url | https://www.e-crt.org/journal/view.php?doi=10.4143/crt.2017.027 | - |
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