Genomic alterations of ground-glass nodular lung adenocarcinoma
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyun | - |
dc.contributor.author | Joung, Je-Gun | - |
dc.contributor.author | Shin, Hyun-Tae | - |
dc.contributor.author | Kim, Duk-Hwan | - |
dc.contributor.author | Kim, Yujin | - |
dc.contributor.author | Kim, Hojoong | - |
dc.contributor.author | Kwon, O. Jung | - |
dc.contributor.author | Shim, Young Mog | - |
dc.contributor.author | Lee, Ho Yun | - |
dc.contributor.author | Lee, Kyung Soo | - |
dc.contributor.author | Choi, Yoon-La | - |
dc.contributor.author | Park, Woong-Yang | - |
dc.contributor.author | Hayes, D. Neil | - |
dc.contributor.author | Um, Sang-Won | - |
dc.date.accessioned | 2021-07-30T05:09:54Z | - |
dc.date.available | 2021-07-30T05:09:54Z | - |
dc.date.created | 2021-05-14 | - |
dc.date.issued | 2018-12 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3294 | - |
dc.description.abstract | In-depth molecular pathogenesis of ground-glass nodular lung adenocarcinoma has not been well understood. The objectives of this study were to identify genomic alterations in ground-glass nodular lung adenocarcinomas and to investigate whether viral transcripts were detected in these tumors. Nine patients with pure (n = 4) and part-solid (n = 5) ground-glass nodular adenocarcinomas were included. Six were females with a median age of 58 years. We performed targeted exon sequencing and RNA sequencing. EGFR (n = 10), IDH2 (n = 2), TP53 (n = 1), PTEN (n = 1), EPHB4 (n = 1), and BRAF (n = 1) were identified as driver mutations by targeted exon sequencing. Vasculogenesis-associated genes including NOTCH4 and TGFBR3 expression were significantly downregulated in adenocarcinoma tissue versus normal tissue (adjusted P values ˂ 0.001 for both NOTCH4 and TGFBR3). In addition, five novel fusion gene loci were identified in four lung adenocarcinomas. However, no significant virus-associated transcripts were detected in tumors. In conclusions, EGFR, IDH2, TP53, PTEN, EPHB4, and BRAF were identified as putative driver mutations of ground-glass nodular adenocarcinomas. Five novel fusion genes were also identified in four tumors. Viruses do not appear to be involved in the tumorigenesis of ground-glass nodular lung adenocarcinoma. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Genomic alterations of ground-glass nodular lung adenocarcinoma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Hyun | - |
dc.identifier.doi | 10.1038/s41598-018-25800-2 | - |
dc.identifier.scopusid | 2-s2.0-85047072214 | - |
dc.identifier.wosid | 000432274300016 | - |
dc.identifier.bibliographicCitation | Scientific Reports, v.8, no.1, pp.1 - 9 | - |
dc.relation.isPartOf | Scientific Reports | - |
dc.citation.title | Scientific Reports | - |
dc.citation.volume | 8 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | INTERNATIONAL-ASSOCIATION | - |
dc.subject.keywordPlus | PROGNOSTIC VALUE | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | CT | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | OPACITY | - |
dc.subject.keywordPlus | PTEN | - |
dc.subject.keywordPlus | BRAF | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.identifier.url | https://www.nature.com/articles/s41598-018-25800-2 | - |
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