Association between metabolic parameters and glomerular hyperfiltration in a representative Korean population without chronic kidney disease
DC Field | Value | Language |
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dc.contributor.author | Hong, Sang mo | - |
dc.contributor.author | Choi Y.M. | - |
dc.contributor.author | Ihm S.-H. | - |
dc.contributor.author | Kim D. | - |
dc.contributor.author | Choi M.-G. | - |
dc.contributor.author | Yu J.M. | - |
dc.contributor.author | Hong E.-G. | - |
dc.date.accessioned | 2021-07-30T05:09:55Z | - |
dc.date.available | 2021-07-30T05:09:55Z | - |
dc.date.created | 2021-05-14 | - |
dc.date.issued | 2018-12 | - |
dc.identifier.issn | 19326203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3295 | - |
dc.description.abstract | Aims To investigate associations of glomerular hyperfiltration with other metabolic factors in a nationally representative dataset. Methods We analyzed cross-sectional data from 15,918 subjects with estimated glomerular filtration rate (eGFR) >60 ml/min/1.73 m2 and urine albumin creation ratio (ACR) <30 mg/g, who participated in the 5th and 6th Korea National Health and Nutrition Examination Surveys. Hyperfiltration was defined as eGFR (CKD-EPI equation) exceeding the age- and sex-specific 95th percentile for healthy control subjects. Results Prevalence of hyperfiltration was 5.2% and that among normal, prediabetic, and diabetic subjects was 4.9%, 5.6%, and 7.3%, respectively, after adjusting for age, sex, and body weight (p for trend = 0.008). In a multiple logistic regression analysis, hyperfiltration was associated with a body mass index ≥30 kg/m2 [odds ratio (OR) = 3.461, p<0.001], waist circumference 85 cm (men) or 80 cm (women) (OR = 1.425, p = 0.015), systolic blood pressure 120–129 mmHg (OR = 1.644, p = 0.022), fasting plasma glucose 140 mg/dL (OR = 1.695, p = 0.033) and t serum triglyceride level 500 mg/dL (OR = 2.988, p = 0.001), and was independently associated with the ACR (B = 0.053, p<0.001). Conclusions In a general Korean population, both hyperfiltration and ACR were associated with similar metabolic parameters, and hyperfiltration correlated independently with a high ACR. Longitudinal studies are needed to further explore risks of hyperfiltration and microalbuminuria. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.title | Association between metabolic parameters and glomerular hyperfiltration in a representative Korean population without chronic kidney disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hong, Sang mo | - |
dc.identifier.doi | 10.1371/journal.pone.0207843 | - |
dc.identifier.scopusid | 2-s2.0-85057728793 | - |
dc.identifier.wosid | 000452307600022 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.13, no.12 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 13 | - |
dc.citation.number | 12 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | RENAL HYPERFILTRATION | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.subject.keywordPlus | RISK | - |
dc.identifier.url | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207843 | - |
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