The effectiveness of transarterial chemoembolization in recurrent hepatocellular-cholangiocarcinoma after resection
DC Field | Value | Language |
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dc.contributor.author | Na, S.K. | - |
dc.contributor.author | Choi, G.H. | - |
dc.contributor.author | Lee, H.C. | - |
dc.contributor.author | Shin, Y.M. | - |
dc.contributor.author | An, Ji hyun | - |
dc.contributor.author | Lee, D. | - |
dc.contributor.author | Shim, J.H. | - |
dc.contributor.author | Kim, K.M. | - |
dc.contributor.author | Lim, Y.-S. | - |
dc.contributor.author | Chung, Y.-H. | - |
dc.contributor.author | Lee, Y.S. | - |
dc.date.accessioned | 2021-07-30T05:10:04Z | - |
dc.date.available | 2021-07-30T05:10:04Z | - |
dc.date.created | 2021-05-14 | - |
dc.date.issued | 2018-06 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3337 | - |
dc.description.abstract | Background Combined hepatocellular-cholangiocarcinoma (cHCC-CC) can present as a hypervascular or peripherally enhancing tumor in dynamic imaging. We evaluated the effect of transarterial chemoembolization (TACE) on prognosis according to post-operative recurrence imaging patterns. Methods We retrospectively analyzed 42 cHCC-CC and 59 hepatocellular carcinoma (HCC-control) patients at the Asan Medical Center. We classified recurrent cHCC-CC according to enhancement pattern (globally enhancing: GE cHCC-CC, peripherally enhancing: PE cHCC-CC) and evaluated tumor response, time-to-local progression (TTPlocal), and overall survival (OS). Results The GE cHCC-CC group had a significantly higher best objective response rate (complete remission + partial response) than the PE cHCC-CC group (36% vs 0%, P= 0.005), and it was comparable to that of the HCC-control group (35.6%, P= 0.97). TTPlocal in the GE cHCC-CC group was significantly shorter than in the HCC-control group (6.6 vs 27.1 months, P ˂ 0.001), and was not significantly different from that in the PE cHCC-CC group (5.3 months, P= 0.12). OS was 12.4 months, 52.8 months, and 67.5 months in the PE cHCC-CC, GE cHCC-CC, and HCC-control groups, respectively (Ps ˂ 0.05). The adjusted hazard ratios (HRs) for TTPlocal and OS revealed an independent association with enhancement pattern of recurrent cHCC-CC (TTPlocal: HR 2.46; 95% CI 1.10-5.46; P= 0.03; OS: HR 5.97; 95% CI 2.38-14.96; P˂ 0.001). Conclusions The GE cHCC-CC group showed better response and prognosis after TACE than the PE cHCC-CC group, but poorer response and prognosis than the HCC-control group. Enhancement patterns at recurrence were crucially associated with tumor response and overall survival. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.title | The effectiveness of transarterial chemoembolization in recurrent hepatocellular-cholangiocarcinoma after resection | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | An, Ji hyun | - |
dc.identifier.doi | 10.1371/journal.pone.0198138 | - |
dc.identifier.scopusid | 2-s2.0-85048205494 | - |
dc.identifier.wosid | 000434384900021 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.13, no.6, pp.1 - 2 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 13 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 2 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | COMPUTED-TOMOGRAPHY | - |
dc.subject.keywordPlus | IMAGING FEATURES | - |
dc.subject.keywordPlus | CLINICOPATHOLOGICAL SIGNIFICANCE | - |
dc.subject.keywordPlus | INTRAHEPATIC CHOLANGIOCARCINOMA | - |
dc.subject.keywordPlus | LIVER-TRANSPLANTATION | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | COMPONENTS | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | PROGNOSIS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.identifier.url | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198138 | - |
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