Impact of edaphic factors and nutrient management on the hepatoprotective efficiency of Carlinoside purified from pigeon pea leaves: An evaluation of UGT1A1 activity in hepatitis induced organelles
DC Field | Value | Language |
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dc.contributor.author | Das, Subhasish | - |
dc.contributor.author | Teja, K. Charan | - |
dc.contributor.author | Mukherjee, Sandip | - |
dc.contributor.author | Seal, Soma | - |
dc.contributor.author | Sah, Rajesh Kumar | - |
dc.contributor.author | Duary, Buddhadeb | - |
dc.contributor.author | Kim, Ki-Hyun | - |
dc.contributor.author | Bhattacharya, Satya Sundar | - |
dc.date.accessioned | 2021-07-30T05:10:17Z | - |
dc.date.available | 2021-07-30T05:10:17Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2018-02 | - |
dc.identifier.issn | 0013-9351 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3399 | - |
dc.description.abstract | Carlinoside is a unique compound well-known for its excellent curative potential in hepatitis. There is a substantial research gap regarding the medicinal use of carlinoside, as its concentrations are greatly variable (depending on locality). We cultivated Cajanus cajan using vermicompost as a major organic amendment at two locations (Sonitpur and Birbhum) with different soil types, but identical climate conditions. Sonitpur soils were richer in soil organic C (SOC), enzyme activation, and N/P content than Birbhum. However, venni-treatment improved many soil properties (bulk density, water retention, pH, N/P/K, and enzyme activity) to narrow the locational gap in soil quality by 15-28%. We also recorded a many-fold increment in SOC storage capacities in both locations, which was significantly correlated with carlinoside, total phenol, and flavonoid contents in Cajanus leaves. This significantly up-regulated the carlinoside induced expression of the bilirubin-solubilizing UGT1A1enzyme in HepG2 cell and rat liver. Leaf extracts of vermicompost-aided plants could cure hepatitis in affected rat livers and in the HepG2 cell line. Accordingly, vermi-treatment is an effective route for the growth of Cajanus as a cash crop for biomedical applications and can produce a concurrent improvement in soil quality. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Impact of edaphic factors and nutrient management on the hepatoprotective efficiency of Carlinoside purified from pigeon pea leaves: An evaluation of UGT1A1 activity in hepatitis induced organelles | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Ki-Hyun | - |
dc.identifier.doi | 10.1016/j.envres.2017.11.054 | - |
dc.identifier.scopusid | 2-s2.0-85037666284 | - |
dc.identifier.wosid | 000423654100059 | - |
dc.identifier.bibliographicCitation | ENVIRONMENTAL RESEARCH, v.161, pp.512 - 523 | - |
dc.relation.isPartOf | ENVIRONMENTAL RESEARCH | - |
dc.citation.title | ENVIRONMENTAL RESEARCH | - |
dc.citation.volume | 161 | - |
dc.citation.startPage | 512 | - |
dc.citation.endPage | 523 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalResearchArea | Public, Environmental & Occupational Health | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.relation.journalWebOfScienceCategory | Public, Environmental & Occupational Health | - |
dc.subject.keywordPlus | SECONDARY METABOLITES | - |
dc.subject.keywordPlus | MEDICINAL-PLANTS | - |
dc.subject.keywordPlus | OBSTRUCTIVE-JAUNDICE | - |
dc.subject.keywordPlus | ORGANIC AMENDMENTS | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | HUMIC ACIDS | - |
dc.subject.keywordPlus | SOIL | - |
dc.subject.keywordPlus | EXPOSURE | - |
dc.subject.keywordPlus | QUALITY | - |
dc.subject.keywordPlus | L. | - |
dc.subject.keywordAuthor | Carlinoside | - |
dc.subject.keywordAuthor | Cajanus cajan | - |
dc.subject.keywordAuthor | Organic fertilization | - |
dc.subject.keywordAuthor | Bilirubin solubilization | - |
dc.subject.keywordAuthor | UGT1A1 expression | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0013935117317231?via%3Dihub | - |
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