Diagnostic accuracy of anti-Sa and anti-RA33 antibodies in rheumatoid arthritis: a meta-analysis

Abstract

Objective This study evaluated the diagnostic accuracy of anti-Sa and anti-RA33 antibodies in rheumatoid arthritis (RA).

Methods PubMed, Embase, and Cochrane library databases were searched for relevant studies, and 2 meta-analyses were performed to determine the diagnostic accuracy of anti-Sa and anti-RA33 antibodies in patients with RA.

Results The meta-analysis included 17 studies. Pooled sensitivity and specificity of anti-Sa antibody were 39.5 % (95 % confidence interval [CI] 36.5–42.4) and 96.8 % (95 % CI 95.9–97.4), respectively, and those of anti-RA33 antibody were 31.8 % (95 % CI 28.7–35.0) and 90.1 % (95 % CI 87.8–92.1), respectively. PLR, NLR, and DOR of anti-Sa antibody were 14.11 (95 % CI 7.076–28.13), 0.607 (95 % CI 0.558–0.703), and 22.76 (95 % C, 11.10–46.69), respectively, and those of anti-RA33 antibody were 3.429 (95 % CI 2.039–5.765), 0.761 (95 % CI 0.681–0.851), and 4.597 (95 % CI 2.602–8.121), respectively. AUC and Q* index for anti-Sa antibody were 0.558 and 0.543, respectively, while those for anti-RA33 antibody were 0.501 and 0.500, respectively.

Conclusions Our meta-analysis indicated that both anti-Sa and anti-RA33 antibodies were highly specific but not sensitive for diagnosing RA.